{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:01:52Z","timestamp":1772769712755,"version":"3.50.1"},"reference-count":85,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,10,3]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Day\u2010to\u2010day variability in sleep patterns and eating timing may disrupt circadian rhythms and has been linked with various adverse cardiometabolic outcomes. However, the extent to which variability in sleep patterns and eating timing relate to atherosclerotic development in subclinical stages remains unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Generally healthy adults (N=62, 29.3\u00b17.3\u2009years, 66% female) completed 14\u2009days of sleep and dietary assessments via wrist accelerometry and photo\u2010assisted diet records, respectively. Variability in sleep duration, sleep onset, eating onset (time of first caloric consumption), eating offset (time of last caloric consumption), and caloric midpoint (time at which 50% of total daily calories are consumed) were operationalized as the SD across 14\u2009days for each variable. Separate regression models evaluated the cross\u2010sectional associations between sleep and eating variability metrics with end\u2010diastolic carotid intima\u2010media thickness (CIMT) measured via ultrasonography. Models adjusted for age, sex, systolic blood pressure, sleep duration, and total energy intake. Each 60\u2010minute increase in sleep duration SD and sleep onset SD were associated with a 0.049\u00b10.016\u2009mm (\n              <jats:italic>P<\/jats:italic>\n              =0.003) and 0.048\u00b10.017\u2009mm (\n              <jats:italic>P<\/jats:italic>\n              =0.007) greater CIMT, respectively. Variability in eating onset and offset were not associated with CIMT; however, each 60\u2010minute increase in caloric midpoint SD was associated with a 0.033\u00b10.015\u2009mm greater CIMT (\n              <jats:italic>P<\/jats:italic>\n              =0.029). Exploratory post hoc analyses suggested that sleep duration SD and sleep onset SD were stronger correlates of CIMT than caloric midpoint SD.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Variability in sleep patterns and eating timing are positively associated with clinically relevant increases in CIMT, a biomarker of subclinical atherosclerosis, in early adulthood.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.029662","type":"journal-article","created":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T10:45:47Z","timestamp":1696070747000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Sleep Variability, Eating Timing Variability, and Carotid Intima\u2010Media Thickness in Early Adulthood"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-7007","authenticated-orcid":false,"given":"Elissa K.","family":"Hoopes","sequence":"first","affiliation":[{"name":"College of Health Sciences University of Delaware Newark DE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9003-8779","authenticated-orcid":false,"given":"Melissa A.","family":"Witman","sequence":"additional","affiliation":[{"name":"College of Health Sciences University of Delaware Newark DE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6166-9627","authenticated-orcid":false,"given":"Michele N.","family":"D'Agata","sequence":"additional","affiliation":[{"name":"College of Health Sciences University of Delaware Newark DE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3056-7142","authenticated-orcid":false,"given":"Benjamin","family":"Brewer","sequence":"additional","affiliation":[{"name":"College of Health Sciences University of Delaware Newark DE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-6678","authenticated-orcid":false,"given":"David G.","family":"Edwards","sequence":"additional","affiliation":[{"name":"College of Health Sciences University of Delaware Newark DE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4044-1399","authenticated-orcid":false,"given":"Shannon M.","family":"Robson","sequence":"additional","affiliation":[{"name":"College of Health Sciences University of Delaware Newark DE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan K.","family":"Malone","sequence":"additional","affiliation":[{"name":"Rory Meyers College of Nursing New York University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3820-8005","authenticated-orcid":false,"given":"Thomas","family":"Keiser","sequence":"additional","affiliation":[{"name":"College of Health Sciences University of Delaware Newark DE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6561-3092","authenticated-orcid":false,"given":"Freda","family":"Patterson","sequence":"additional","affiliation":[{"name":"College of Health Sciences University of Delaware Newark DE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001052"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806043382302"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.10.013"},{"key":"e_1_3_2_6_2","first-page":"266","article-title":"World health organization (WHO) and the world heart federation (WHF) pathobiological determinants of atherosclerosis in youth (PBDAY) study. 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