{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:01:06Z","timestamp":1793779266388,"version":"4.6.1"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,11,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cardiovascular complications after acute ischemic stroke (AIS) can be related to chronic\/comorbid cardiac conditions or acute disruption of the brain\u2013heart autonomic axis (stroke\u2010heart syndrome). Women are known to be more vulnerable to certain stress\u2010induced cardiac complications, such as Takotsubo cardiomyopathy. We investigated sex differences in cardiac troponin (cTn) elevation, cardiac events, and outcomes after AIS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We retrospectively analyzed consecutive patients with AIS from 5 stroke centers. Patients with AIS with elevated baseline cTn and at least 2 cTn measurements were included, while patients with acute comorbid conditions that could impact cTn levels were excluded. Poststroke acute myocardial injury was defined as the presence of a dynamic cTn pattern (rise\/fall &gt;20% in serial measurements) in the absence of acute atherosclerotic coronary disease (type 1 myocardial infarction) or cardiac death (type 3 myocardial infarction). From a total cohort of 3789 patients with AIS, 300 patients were included in the study: 160 were women (53%). Women were older, had a lower burden of cardiovascular risk factors, and more frequently had cardioembolic stroke and right insula involvement (\n                      <jats:italic>P<\/jats:italic>\n                      values all &lt;0.05). In multivariate analysis, women were more likely to have a dynamic cTn pattern (adjusted odds ratio, 2.1 [95% CI, 1.2\u20133.6]) and develop poststroke acute myocardial injury (adjusted odds ratio, 2.1 [95% CI, 1.1\u20133.8]). Patients with poststroke acute myocardial injury had higher 7\u2010day mortality (adjusted odds ratio, 5.5 [95% CI, 1.2\u201324.4]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In patients with AIS with elevated cTn at baseline, women are twice as likely to develop poststroke acute myocardial injury, and this is associated with higher risk of short\u2010term mortality. Translational studies are needed to clarify mechanisms underlying sex differences in cardiac events and mortality in AIS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.029799","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T06:28:24Z","timestamp":1697610504000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Stroke\u2010Heart Syndrome: Does Sex Matter?"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3359-9094","authenticated-orcid":false,"given":"Michela","family":"Rosso","sequence":"first","affiliation":[{"name":"Department of Neurology University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3307-5354","authenticated-orcid":false,"given":"Srinath","family":"Ramaswamy","sequence":"additional","affiliation":[{"name":"Department of 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