{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T09:51:04Z","timestamp":1779011464726,"version":"3.51.4"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,1,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Mitral regurgitation (MR) is the most common valvular disease in the United States and increases the risk of death and hospitalization. The economic burden of MR in the United States is not known.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We analyzed inpatient hospitalization data from the 1\u2009221\u2009173 Maryland residents who had any in\u2010state admissions from October 1, 2015, to September 30, 2019. We assessed the total charges for patients without MR and for patients with MR who underwent medical management, transcatheter mitral valve repair or replacement, or surgical mitral valve repair or replacement. During the study period, 26\u2009076 inpatients had a diagnosis of MR. Compared with patients without MR, these patients had more comorbidities and higher inpatient mortality. Patients with medically managed MR incurred average total charges of $23\u2009575 per year; MR was associated with $10\u2009559 more in charges per year and an incremental 3.1 more inpatient days per year as compared with patients without MR. Both surgical mitral valve repair or replacement and transcatheter mitral valve repair or replacement were associated with higher charges as compared with medical management during the year of intervention ($47\u2009943 for surgical mitral valve repair or replacement and $63\u2009108 for transcatheter mitral valve repair or replacement). Annual charges for both groups were significantly lower as compared with medical management in the second and third years postintervention.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">MR is associated with higher mortality and inpatient charges. Patients who undergo surgical or transcatheter intervention incur lower charges compared with medically managed MR patients in the years after the procedure.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.029875","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T11:13:41Z","timestamp":1705058021000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Economic Burden of Inpatient Care for Mitral Regurgitation in Maryland"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0619-426X","authenticated-orcid":false,"given":"Radoslav","family":"Zinoviev","sequence":"first","affiliation":[{"name":"Division of Cardiology University of California Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0516-9855","authenticated-orcid":false,"given":"Rani K.","family":"Hasan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Gammie","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-5420","authenticated-orcid":false,"given":"Jon R.","family":"Resar","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8039-4956","authenticated-orcid":false,"given":"Matthew J.","family":"Czarny","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/CEOR.S112691"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(98)01064-9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(07)70830-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192667"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.08.039"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-004984"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30473-2"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.09.021"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.04.022"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.033"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.061"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/pan\/mpr025"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2014.09.008"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2014.923892"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2016.1227828"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2016.1157484"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-015-0039-8"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2014.980502"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.117.004466"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043275"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2017.04.012"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-019-01603-x"},{"key":"e_1_3_2_26_2","unstructured":"United States Census Bureau . QuickFacts: Maryland Populations Estimates V2022. Accessed November 2 2022. https:\/\/www.census.gov\/quickfacts\/MD. Published July 1 2022."}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.029875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:34:16Z","timestamp":1715603656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.029875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,16]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1,16]]}},"alternative-id":["10.1161\/JAHA.123.029875"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.029875","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,16]]},"assertion":[{"value":"2023-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e029875"}}