{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:22:38Z","timestamp":1782451358202,"version":"3.54.5"},"reference-count":69,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Prior studies have reported the cross\u2010sectional relationship between lung function and arterial stiffness, while the longitudinal association remains unclear to date. This study aimed to investigate whether abnormal lung function and its subtypes at baseline are associated with increased arterial stiffness using a cohort.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">This was a secondary analysis extracting 2461 participants from Beijing Health Management Cohort as baseline and annually followed for development of arterial stiffness. Abnormal lung function was defined by forced expiratory volume in 1s &lt;80% of the predicted value, forced vital capacity of the predicted value, or forced expiratory volume in 1s\/forced vital capacity ratio &lt;70%. Increased arterial stiffness was determined by brachial\u2010ankle pulse wave velocity \u22651400\u2009cm\/s. Cox proportional hazards model was used to calculate the hazard ratio and population attributable fraction. The mean age was 42.8\u00b18.1\u2009years, and 444 (18.0%) cases developed increased arterial stiffness during a median follow\u2010up of 3.0\u2009years. The adjusted hazard ratio (95% CI) of arterial stiffness was 1.47 (95% CI, 1.10\u20131.96) for abnormal lung function, with a population attributable fraction of 3.9% (95% CI, 0.8\u20137.1). Of subtypes, only obstructive ventilatory dysfunction was significantly associated with arterial stiffness (adjusted hazard ratio, 2.06 [95% CI, 1.27\u20133.36]), not restricted ventilatory dysfunction (adjusted hazard ratio, 0.95 [95% CI, 0.54\u20131.65]). Consistent results were observed on multiple sensitivity analyses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Our study indicated a longitudinal association of abnormal lung function with increased arterial stiffness using a large cohort, especially for the obstructive ventilatory dysfunction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.029929","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T10:19:25Z","timestamp":1703845165000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Association of Abnormal Lung Function and Its Subtypes With Arterial Stiffness: A Longitudinal Cohort Study"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5694-2441","authenticated-orcid":false,"given":"Zhiyuan","family":"Wu","sequence":"first","affiliation":[{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health Capital Medical University Beijing China"},{"name":"Centre for Precision Health, School of Medical and Health Sciences Edith Cowan University Joondalup Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Jiang","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-681X","authenticated-orcid":false,"given":"Zhiwei","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutao","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Fufan Information Technology Co. 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