{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:58:35Z","timestamp":1790888315355,"version":"4.1.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,9,19]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Triglyceride and glucose (TyG) index and TyG\u2010related indices combined with obesity\u2010related markers are considered important markers of insulin resistance. We aimed to examine the association between the TyG index and modified TyG indices with new\u2010onset hypertension and their predictive ability stratified by sex.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We analyzed data from 5414 Korean Genome and Epidemiology Study participants aged 40 to 69\u2009years. Multiple Cox proportional hazard regression analyses were conducted to estimate\u00a0the hazard ratio (HR) and 95% CI for new\u2010onset hypertension according to sex\u2010specific tertile groups after confounder adjustments. To evaluate the predictive performance of these indices for new\u2010onset hypertension, we calculated Harrell's C\u2010index (95% CI). Over a 9.5\u2010year follow\u2010up period, 1014 men and 1012 women developed new\u2010onset hypertension. Compared with the lowest tertile (T) group, the adjusted HR and 95% CI for new\u2010onset hypertension in T3 for TyG, TyG\u2010body mass index, TyG\u2010waist circumference, and TyG\u2010waist\u2010to\u2010height ratio were 1.16 (0.95\u20131.40), 1.11 (0.84\u20131.48), 1.77 (1.38\u20132.27), and 1.68 (1.33\u20132.13) in men and 1.37 (1.13\u20131.66), 1.55 (1.16\u20132.06), 1.43 (1.15\u20131.79), and 1.64 (1.30\u20132.07) in women, respectively. The C\u2010indices of TyG\u2010waist\u2010to\u2010height ratio for new\u2010onset hypertension were significantly higher than those of TyG and TyG\u2010body mass index in both men and women.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">TyG and TyG\u2010body mass index were significantly associated with new\u2010onset hypertension only in women. TyG\u2010waist circumference and TyG\u2010waist\u2010to\u2010height ratio were significantly associated with new\u2010onset hypertension in both men and women. A sex\u2010specific approach is required when using TyG and modified TyG indices to identify individuals at risk of incident hypertension.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.030022","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T10:11:56Z","timestamp":1695031916000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Sex\u2010Specific Comparison Between Triglyceride Glucose Index and Modified Triglyceride Glucose Indices to Predict New\u2010Onset Hypertension in Middle\u2010Aged and Older Adults"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3322-1774","authenticated-orcid":false,"given":"Joo Hyung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Yongin Severance Hospital Yonsei University College of Medicine Yongin Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8764-7995","authenticated-orcid":false,"given":"Seok\u2010Jae","family":"Heo","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Biomedical Systems Informatics Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9021-3856","authenticated-orcid":false,"given":"Yu\u2010Jin","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Yongin Severance Hospital Yonsei University College of Medicine Yongin Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0244-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(21)01330-1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200001063420101"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.119.14240"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(15)01225-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01268-9"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0840"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.6.1487"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-018-0376-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/met.2008.0034"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-019-0957-3"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01006-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-020-0326-4"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2017.1324477"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-017-0562-y"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0000000000000941"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01077-6"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149731"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-1020-8"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-021-02815-w"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01054-z"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4921-2"},{"key":"e_1_3_2_24_2","first-page":"532","article-title":"Validity and reliability of Korean version of International Physical Activity Questionnaire (IPAQ) short form","volume":"28","author":"Oh JY","year":"2007","unstructured":"Oh JY, Yang YJ, Kim BS, Kang JH. 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