{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:22:17Z","timestamp":1793499737687,"version":"4.5.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Pulmonary hypertension (PH) is highly prevalent in patients with heart failure with preserved ejection fraction (HFpEF), and it is a strong predictor of adverse outcomes. We aimed to determine possible echocardiographic parameters to predict the presence of PH in patients with HFpEF<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">A total of 113 patients with HFpEF were prospectively enrolled from November 2017 to July 2022. The patients underwent invasive cardiac catheterization and simultaneous echocardiography at rest and during exercise. The parameters indicating right ventricle\u2010pulmonary artery uncoupling, including tricuspid annular plane systolic excursion (TAPSE)\/pulmonary artery systolic pressure (PASP) and tricuspid annular systolic velocity (TAS\u2019)\/PASP were calculated. Receiver operating characteristic curve analysis was used to determine the optimal cut\u2010off points of TAPSE\/PASP and TAS\u2019\/PASP to differentiate patients with HFpEF with PH from those without PH. Sixty\u2010eight patients with HFpEF with PH and 45 without PH were included. Those with PH had lower TAPSE\/PASP and TAS\u2019\/PASP at rest and during exercise compared with those without PH. Both resting\/stress TAPSE\/PASP and TAS\u2019\/PASP were correlated with rest\/exercise pulmonary capillary wedge pressure and mean pulmonary artery pressure. In multivariable regression analysis, TAPSE\/PASP remained a significant predictor of exercise pulmonary capillary wedge pressure and mean pulmonary artery pressure. In receiver operating characteristic curve analysis, the optimal cut\u2010off points of TAPSE\/PASP and TAS\u2019\/PASP to differentiate patients with HFpEF with PH from those without PH were \u22640.62 and \u22640.47, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Right ventricle\u2010pulmonary artery uncoupling is closely correlated with abnormal rest\/exercise hemodynamics (pulmonary capillary wedge pressure and mean pulmonary artery pressure) in patients with HFpEF. TAPSE\/PASP and TAS\u2019\/PASP can be useful parameters to detect PH in patients with HFpEF.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.030025","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T10:01:26Z","timestamp":1703844086000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Right Ventricular\u2010Vascular Uncoupling Predicts Pulmonary Hypertension in Clinically Diagnosed Heart Failure With Preserved Ejection Fraction"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7728-6674","authenticated-orcid":false,"given":"Zheng\u2010Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University College of Medicine and Hospital Taipei Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital, Yun\u2010Lin Branch Dou\u2010Liu Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9885-3543","authenticated-orcid":false,"given":"Yi\u2010Wei","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University College of Medicine and Hospital Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital, Hsin\u2010Chu Branch Hsin\u2010Chu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9729-5551","authenticated-orcid":false,"given":"Jen\u2010Fang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University College of Medicine and Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0121-1761","authenticated-orcid":false,"given":"Chen\u2010Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University College of Medicine and Hospital Taipei Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine Cathay General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8025-6211","authenticated-orcid":false,"given":"Ssu\u2010Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine &amp; Rehabilitation Fu Jen Catholic University Hospital and Fu Jen Catholic University School of Medicine New Taipei City Taiwan"},{"name":"Department of Physical Medicine &amp; Rehabilitation National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7505-6429","authenticated-orcid":false,"given":"Lian\u2010Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University College of Medicine and Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6908-1599","authenticated-orcid":false,"given":"Hung\u2010Chun","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3867-150X","authenticated-orcid":false,"given":"Cho\u2010Kai","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University College of Medicine and Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-0363-2"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000001063"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.113.000823"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.11.051"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu193"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00583.2020"},{"key":"e_1_3_1_9_2","first-page":"272","article-title":"Echocardiographic evaluation of right ventricular\u2010arterial coupling in pulmonary hypertension","volume":"10","author":"Todaro MC","year":"2020","unstructured":"Todaro MC, Carerj S, Zito C, Trifir\u00f2 MP, Consolo G, Khandheria B. 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