{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:27:33Z","timestamp":1789774053954,"version":"4.0.1"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,11,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Data on clinical outcomes after transcatheter aortic valve replacement (TAVR) in specific cancer types or the presence of metastatic disease remain sparse. This study aimed to investigate the impact of active cancer on short\u2010term mortality, complications, and readmission rates after TAVR across different cancer types.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The authors assessed the Nationwide Readmissions Database for TAVR cases from 2012 to 2019. Patients were stratified by specific cancer types. Primary outcome was in\u2010hospital mortality. Secondary outcomes included bleeding requiring blood transfusion and readmissions at 30, 90, and 180\u2009days after TAVR. Overall, 122\u2009573 patients undergoing TAVR were included in the analysis, of whom 8013 (6.5%) had active cancer. After adjusting for potential confounders, the presence of active cancer was not associated with increased in\u2010hospital mortality (adjusted odds ratio [aOR], 1.06 [95% CI, 0.89\u20131.27];\n              <jats:italic>P<\/jats:italic>\n              =0.523). However, active cancer was associated with an increased risk of readmission at 30, 90, and 180\u2009days after TAVR and increased risk of bleeding requiring transfusion at 30\u2009days. Active colon and any type of metastatic cancer were individually associated with readmissions at 30, 90, and 180\u2009days after TAVR. At 30\u2009days after TAVR, colon (aOR, 2.51 [95% CI, 1.68\u20133.76];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), prostate (aOR, 1.40 [95% CI, 1.05\u20131.86];\n              <jats:italic>P<\/jats:italic>\n              =0.021), and any type of metastatic cancer (aOR, 1.65 [95% CI, 1.23\u20132.22];\n              <jats:italic>P<\/jats:italic>\n              =0.001) were individually associated with an increased risk of bleeding requiring transfusion.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients with active cancer had similar in\u2010hospital mortality after TAVR but higher risk of readmission and bleeding requiring transfusion, the latter depending on certain types of cancer.<\/jats:p>\n          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