{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:59:30Z","timestamp":1788238770389,"version":"build-2803163510"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,8,15]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The associations of oral contraceptive (OC) use with cardiovascular disease (CVD) and all\u2010cause death remains unclear. We aimed to determine the associations of OC use with incident CVD and all\u2010cause death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      This cohort study included 161\u2009017 women who had no CVD at baseline and reported their OC use. We divided OC use into ever use and never use. Cox proportional hazard models were used to calculate hazard ratios and 95% CIs for cardiovascular outcomes and death. Overall, 131\u2009131 (81.4%) of 161\u2009017 participants reported OC use at baseline. The multivariable\u2010adjusted hazard ratios for OC ever users versus never users were 0.92 (95% CI, 0.86\u20130.99) for all\u2010cause death, 0.91 (95% CI, 0.87\u20130.96) for incident CVD events, 0.88 (95% CI, 0.81\u20130.95) for coronary heart disease,\u00a00.87 (95% CI, 0.76\u20130.99) for heart failure, and 0.92 (95% CI, 0.84\u20130.99) for atrial fibrillation. However, no significant associations of OC use with CVD death, myocardial infarction, or stroke were observed. Furthermore, the associations of OC use with CVD events were stronger among participants with longer durations of use (\n                      <jats:italic>P<\/jats:italic>\n                      for trend&lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">OC use was not associated with an increased risk of CVD events and all\u2010cause death in women and may even produce an apparent net benefit. In addition, the beneficial effects appeared to be more apparent in participants with longer durations of use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.030105","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T06:34:21Z","timestamp":1691649261000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["Associations of Oral Contraceptive Use With Cardiovascular Disease and All\u2010Cause Death: Evidence From the UK Biobank Cohort Study"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3754-1068","authenticated-orcid":false,"given":"Weijuan","family":"Dou","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Nanfang Hospital Southern Medical University Guangzhou China"},{"name":"Department of Endocrinology, Jinling Hospital Medical School of Nanjing University Nanjing 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