{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T12:50:13Z","timestamp":1787403013294,"version":"build-2736575974"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,8,15]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The impact of changes in Doppler\u2010derived kidney venous flow in heart failure (HF) is not well studied. We aimed to investigate the association of Doppler\u2010derived kidney venous stasis index (KVSI) and intrakidney venous\u2010flow (IKVF) patterns with adverse cardiorenal outcomes in patients with HF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">In this observational cohort study, consecutive inpatients with HF referred to a nephrologist because of a history of diuretic resistance and abnormal kidney function (n=216) underwent spectral kidney assessments after admission (Doppler 1) and 25 to 35\u2009days later (Doppler 2) to identify IKVF patterns (continuous\/pulsatile\/biphasic\/monophasic) and KVSI levels. Cox proportional hazard regression models were used to evaluate the associations between KVSI\/IKVF patterns at Doppler 1 as well as changes from Doppler 1 to Doppler 2 and risk of cardiorenal events up to 18\u2009months after admission. Worsening HF or death occurred in 126 patients. Both baseline KVSI (hazard ratio [HR], 1.49 [95% CI, 1.37\u20131.61] per 0.1\u2010unit increase) and baseline IKVF pattern (HR, 2.47 [95% CI, 2.01\u20133.04] per 1 pattern severity increase) were significantly associated with worsening HF\/death. Increases in both KVSI and IKVF pattern severity from Doppler 1 to 2 were also associated with an increased risk of worsening HF\/death (HR, 3.00 [95% CI, 2.08\u20134.32] per 0.1\u2010unit increase change; and HR, 6.73 [95% CI, 3.27\u201313.86] per 1 pattern increase in severity change, respectively). Similar results were observed for kidney outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Baseline kidney venous flow predicted adverse cardiorenal events, and inclusion of serial kidney venous flow in cardiorenal risk stratification could facilitate clinical decision\u2010making for patients with HF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT03039959.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.030145","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T09:50:22Z","timestamp":1692006622000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Changes in Doppler\u2010Derived Kidney Venous Flow and Adverse Cardiorenal Outcomes in Patients With Heart Failure"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6742-5052","authenticated-orcid":false,"given":"Faeq","family":"Husain\u2010Syed","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II University Hospital Giessen and Marburg, Justus\u2010Liebig\u2010University Giessen Giessen Germany"},{"name":"Division of Nephrology University of Virginia School of Medicine Charlottesville VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6289-2273","authenticated-orcid":false,"given":"Narayana 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