{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:02:19Z","timestamp":1792047739975,"version":"4.4.0"},"reference-count":88,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,7,4]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">High and low birth weight are independently associated with increased cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential (CHIP), the age\u2010related clonal expansion of hematopoietic cells with preleukemic somatic mutations, predicts incident cardiovascular disease independent of traditional cardiovascular risk factors. Whether birth weight predicts development of CHIP later in life is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 221\u2009047 adults enrolled in the UK Biobank with whole exome sequences and self\u2010reported birth weight were analyzed. Of those, 22\u2009030 (11.5%) had low (&lt;2.5\u2009kg) and 29\u2009292 (14.7%) high birth weight (&gt;4.0\u2009kg). CHIP prevalence was higher among participants with low (6.0%,\n              <jats:italic>P<\/jats:italic>\n              =0.049) and high (6.3%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) versus normal birth weight (5.7%, ref.). Multivariable\u2010adjusted logistic regression analyses demonstrated that each 1\u2010kg increase in birth weight was associated with a 3% increased risk of CHIP (odds ratio, 1.03 [95% CI, 1.00\u20131.06];\n              <jats:italic>P<\/jats:italic>\n              =0.04), driven by a stronger association observed between birth weight and\n              <jats:italic>DNMT3A<\/jats:italic>\n              CHIP (odds ratio, 1.04 per 1\u2010kg increase [95% CI, 1.01\u20131.08];\n              <jats:italic>P<\/jats:italic>\n              =0.02). Mendelian randomization analyses supported a causal relationship of longer gestational age at delivery with\n              <jats:italic>DNMT3A<\/jats:italic>\n              CHIP. Multivariable Cox regression demonstrated that CHIP was independently and additively associated with incident cardiovascular disease or death across birth weight groups, with highest absolute risks in those with CHIP plus high or low birth weight.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Higher birth weight is associated with increased risk of developing CHIP in midlife, especially\n              <jats:italic>DNMT3A<\/jats:italic>\n              CHIP. These findings identify a novel risk factor for CHIP and provide insights into the relationships among early\u2010life environment, CHIP, cancer, and cardiovascular disease.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.030220","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T23:17:59Z","timestamp":1687475879000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8146-9692","authenticated-orcid":false,"given":"Art","family":"Schuermans","sequence":"first","affiliation":[{"name":"Program in Medical and Population Genetics and Cardiovascular Disease Initiative Broad Institute of Harvard and MIT Cambridge MA USA"},{"name":"Cardiovascular Research Center 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