{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:45:09Z","timestamp":1753883109926,"version":"3.41.2"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,8,15]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Premature ventricular contractions (PVCs) and nonsustained ventricular tachycardia (NSVT) are known to be associated with reduced left ventricular (LV) ejection fraction and adverse outcomes in patients with structural heart disease. The relationship between subclinical LV dysfunction and ventricular arrhythmias in the general population is not established.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Participants in the SAFARIS (Subclinical Atrial Fibrillation and Risk of Ischemic Stroke) study with normal left ventricular ejection fraction (n=503; mean age 77\u2009years, 63% women) underwent 14\u2010day electrocardiographic monitoring and 2\u2010dimensional echocardiography. Frequent PVCs were defined as PVCs &gt;500 per 24\u2009hours and NSVT as \u22654 consecutive ventricular ectopic beats. Reduced LV global longitudinal strain (GLS) was used as an indicator of subclinical LV dysfunction. Seventy\u2010six participants (15.1%) had PVCs &gt;500\/d, 117 (23.3%) had NSVT episodes. LV GLS was significantly reduced in both frequent PVCs and NSVT groups (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). In multivariable analyses, lower LV GLS was associated with frequent PVCs (adjusted odds ratio [aOR], 1.19 [95% CI, 1.09\u20131.30 per unit reduction];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and NSVT (aOR, 1.09 [95% CI, 1.01\u20131.17];\n              <jats:italic>P<\/jats:italic>\n              =0.036) independently of established risk factors and other echocardiographic parameters. Abnormal LV GLS (&gt;\u221215.8%) carried a 2\u2010fold increase in risk of ventricular arrhythmias (aOR, 2.18,\n              <jats:italic>P<\/jats:italic>\n              =0.029 for PVCs; aOR, 2.09,\n              <jats:italic>P<\/jats:italic>\n              =0.026 for NSVT).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">PVCs and NSVT episodes were frequent in this community\u2010based elderly cohort with normal left ventricular ejection fraction and were independently associated with lower LV GLS. The association between LV dysfunction and ventricular arrhythmias is present at an early, subclinical stage, an observation that carries possible preventative implications.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.030274","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T09:49:45Z","timestamp":1692006585000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Subclinical Left Ventricular Dysfunction and Ventricular Arrhythmias in Older Adults With Normal Ejection Fraction"],"prefix":"10.1161","volume":"12","author":[{"given":"Yuriko","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Medicine Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhezhen","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5787-8004","authenticated-orcid":false,"given":"Koki","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichi","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1324-1869","authenticated-orcid":false,"given":"Carlo","family":"Mannina","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Shames","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2562-1156","authenticated-orcid":false,"given":"Mitchell S. 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