{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:52:24Z","timestamp":1790905944212,"version":"4.1.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,9,5]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The impact of medical record\u2010based frailty assessment on clinical outcomes in patients undergoing revascularization for critical limb\u2010threatening ischemia (CLTI) is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This study included patients with CLTI aged \u226518 years from the nationwide readmissions database 2016 to 2018 who underwent endovascular revascularization (ER) or surgical revascularization (SR). The hospital frailty risk score, a previously validated\n              <jats:italic>International Classification of Diseases, Tenth Edition, Clinical Modification (ICD\u201010\u2010CM<\/jats:italic>\n              ) claims\u2010based score, was used to categorize patients into low\u2010 (&lt;5), intermediate\u2010 (5\u201315), and high\u2010risk (&gt;15) frailty categories. Primary outcomes were in\u2010hospital mortality and major amputation at 6 months. A total of 64 338 patients were identified who underwent ER (82.3%) or SR (17.7%) for CLTI. The mean (SD) age of the cohort was 69.3 (11.8) years, and 63% of patients were male. This study found a nonlinear association between hospital frailty risk score and in\u2010hospital mortality and 6\u2010month major amputation. In both ER and SR cohorts, the intermediate\u2010 and high\u2010risk groups were associated with a significantly higher risk of in\u2010hospital mortality (high\u2010risk group: ER: odds ratio [OR], 7.2 [95% CI, 4.4\u201311.6],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; SR: OR, 28.6 [95% CI, 3.4\u2013237.6],\n              <jats:italic>P<\/jats:italic>\n              =0.002) and major amputation at 6 months (high\u2010risk group: ER: hazard ratio [HR], 1.6 [95% CI, 1.5\u20131.7],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; SR: HR, 1.7 [95% CI, 1.4\u20132.2],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) compared with the low\u2010risk group.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The hospital frailty risk score, generated from the medical record, can identify frailty and predict in\u2010hospital mortality and 6\u2010month major amputation in patients undergoing ER or SR for CLTI. Further studies are needed to assess if this score can be incorporated into clinical decision\u2010making in patients undergoing revascularization for CLTI.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.030294","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T09:42:22Z","timestamp":1693302142000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Prognostic Value of Hospital Frailty Risk Score and Clinical Outcomes in Patients Undergoing Revascularization for Critical Limb\u2013Threatening Ischemia"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5389-5878","authenticated-orcid":false,"given":"Monil","family":"Majmundar","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine University of Kansas Medical Center Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2712-0670","authenticated-orcid":false,"given":"Kunal N.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine West Virginia University Morgantown WV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-2750","authenticated-orcid":false,"given":"Rajkumar","family":"Doshi","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Joseph\u2019s University Medical Center Paterson NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2136-4183","authenticated-orcid":false,"given":"Harsh","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Kansas Medical Center Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6163-9789","authenticated-orcid":false,"given":"Mohinder R.","family":"Vindhyal","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Kansas Medical Center Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk A","family":"Hance","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Vascular Surgery University of Kansas Medical Center KS Kansas City USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Kansas Medical Center Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2440-9033","authenticated-orcid":false,"given":"Kamal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Kansas Medical Center Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009724"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.12.037"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-006-0242-y"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.07.062"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.04.074"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.08.169"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.006778"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.04.048"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1708538120988228"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X221083701"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30668-8"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(20)30146-8"},{"key":"e_1_3_2_14_2","unstructured":"Introduction to the HCUP Nationwide Readmissions Database (NRD) 2010\u20132018. 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