{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:04:29Z","timestamp":1790633069377,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,11,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Mental stress\u2013induced myocardial ischemia is a frequent phenomenon in patients with coronary artery disease and is associated with a greater risk of future cardiovascular events. The association between chronic symptoms of psychological distress and mental stress\u2013induced ischemia is not clear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We used a composite score of psychological distress derived from symptoms of depression, posttraumatic stress disorder, anxiety, anger, and perceived general stress. Participants underwent myocardial perfusion imaging with both mental (public speaking task) and conventional (exercise or pharmacological) stress testing. Overall, 142 (15.9%) patients experienced mental stress\u2013induced myocardial ischemia. After adjusting for demographic factors, medical history, and medication use, patients in the highest tertile of psychological distress score had 35% higher odds of having mental stress\u2013induced ischemia compared to those in the lowest tertile (odds ratio [OR], 1.35 [95% CI, 1.06\u20132.22]). Stratified analyses showed that the association between psychological distress score and mental stress\u2013induced myocardial ischemia was significantly associated only within the subgroup of patients with a prior myocardial infraction, with patients with a prior myocardial infarction in the highest tertile having a 93% higher odds of developing myocardial ischemia with mental stress (95% CI, 1.07\u20133.60). There was no significant association between psychological distress and conventional stress\u2013induced ischemia (OR, 1.19 [95% CI, 0.87\u20131.63]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among patients with a history of myocardial infarction, a higher level of psychosocial distress is associated with mental stress\u2013induced myocardial ischemia but not with ischemia induced by a conventional stress test.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.030305","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T11:11:55Z","timestamp":1699269115000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Association Between Symptoms of Chronic Psychological Distress and Myocardial Ischemia Induced by Mental Stress in Patients With Coronary Artery Disease"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0328-2050","authenticated-orcid":false,"given":"Kasra","family":"Moazzami","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine Emory Clinical Cardiovascular Research Institute Atlanta GA"},{"name":"Grady Health System Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Garcia","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Emory Clinical Cardiovascular Research Institute Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9427-7235","authenticated-orcid":false,"given":"Samaah","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health The University of Texas Health Science Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ten\u00e9 T.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health Emory University Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1633-6433","authenticated-orcid":false,"given":"J. 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