{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:06Z","timestamp":1787018106072,"version":"build-2736575974"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,12,19]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The relationship between depression and subclinical coronary atherosclerosis in asymptomatic individuals is not clear. We evaluated this relationship in a Korean population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We analyzed 3920 individuals (mean age 54.7\u00b17.9\u2009years and 2603 men [66.4%]) with no history of coronary artery disease who voluntarily underwent coronary computed tomographic angiography and screening for depression using the Beck Depression Inventory as part of a general health examination. The degree and extent of subclinical coronary atherosclerosis were evaluated by coronary computed tomographic angiography, and \u226550% diameter stenosis was defined as significant. Participants were categorized into groups of those with or without depression using the Beck Depression Inventory scores \u226516 as a cutoff value. Of the study participants, 272 (6.9%) had a Beck Depression Inventory score of 16 or higher. After adjustment for cardiovascular risk factors, depression was not significantly associated with any coronary plaque (adjusted odds ratio [OR], 1.05 [95% CI, 0.78\u20131.41];\n                      <jats:italic>P<\/jats:italic>\n                      =0.746), calcified plaque (OR, 0.95 [95% CI, 0.71\u20131.29];\n                      <jats:italic>P<\/jats:italic>\n                      =0.758), noncalcified plaque (OR, 1.31 [95% CI, 0.79\u20132.17];\n                      <jats:italic>P<\/jats:italic>\n                      =0.305), mixed plaque (OR, 1.16 [95% CI, 0.60\u20132.23];\n                      <jats:italic>P<\/jats:italic>\n                      =0.659), or significant coronary artery stenosis (OR, 1.22 [95% CI, 0.73\u20132.03];\n                      <jats:italic>P<\/jats:italic>\n                      =0.450). In the propensity score\u2010matched population (n=1318) as well, none of the coronary artery disease measures of subclinical coronary atherosclerosis were statistically significantly associated with depression (all\n                      <jats:italic>P<\/jats:italic>\n                      &gt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this large cross\u2010sectional study with asymptomatic individuals undergoing coronary computed tomographic angiography and Beck Depression Inventory evaluation, depression was not associated with an increased risk of subclinical coronary atherosclerosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.030315","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T06:07:26Z","timestamp":1702015646000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Depression and Subclinical Coronary Atherosclerosis in Adults Without Clinical Coronary Artery Disease"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5370-005X","authenticated-orcid":false,"given":"Jangho","family":"Park","sequence":"first","affiliation":[{"name":"Department of Psychiatry Ulsan University Hospital, University of Ulsan College of Medicine Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6584-1471","authenticated-orcid":false,"given":"Hyeji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Ulsan University Hospital, University of 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