{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:44:24Z","timestamp":1777099464921,"version":"3.51.4"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,2,6]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Despite longstanding epidemiologic data on the association between increased serum triglycerides and cardiovascular events, the exact level at which risk begins to rise is unclear. The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension has conceived a protocol aimed at searching for the prognostic cutoff value of triglycerides in predicting cardiovascular events in a large regional\u2010based Italian cohort.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Among 14\u2009189 subjects aged 18 to 95\u2009years followed\u2010up for 11.2 (5.3\u201313.2) years, the prognostic cutoff value of triglycerides, able to discriminate combined cardiovascular events, was identified by means of receiver operating characteristic curve. The conventional (150\u2009mg\/dL) and the prognostic cutoff values of triglycerides were used as independent predictors in separate multivariable Cox regression models adjusted for age, sex, body mass index, total and high\u2010density lipoprotein cholesterol, serum uric acid, arterial hypertension, diabetes, chronic renal disease, smoking habit, and use of antihypertensive and lipid\u2010lowering drugs. During 139\u2009375 person\u2010years of follow\u2010up, 1601 participants experienced cardiovascular events. Receiver operating characteristic curve showed that 89\u2009mg\/dL (95% CI, 75.8\u2013103.3, sensitivity 76.6, specificity 34.1,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) was the prognostic cutoff value for cardiovascular events. Both cutoff values of triglycerides, the conventional and the newly identified, were accepted as multivariate predictors in separate Cox analyses, the hazard ratios being 1.211 (95% CI, 1.063\u20131.378,\n              <jats:italic>P<\/jats:italic>\n              =0.004) and 1.150 (95% CI, 1.021\u20131.295,\n              <jats:italic>P<\/jats:italic>\n              =0.02), respectively.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Lower (89\u2009mg\/dL) than conventional (150\u2009mg\/dL) prognostic cutoff value of triglycerides for cardiovascular events does exist and is associated with increased cardiovascular risk in an Italian cohort.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.030319","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T11:16:12Z","timestamp":1706699772000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Prognostic Value and Relative Cutoffs of Triglycerides Predicting Cardiovascular Outcome in a Large Regional\u2010Based Italian Database"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7846-0101","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Tikhonoff","sequence":"first","affiliation":[{"name":"Department of Medicine Universit\u00e0 degli Studi di Padova Via Giustiniani 8 Padua 35128 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0003-3289","authenticated-orcid":false,"given":"Edoardo","family":"Casiglia","sequence":"additional","affiliation":[{"name":"Studium Patavinum, Department of Medicine Universit\u00e0 degli Studi di Padova Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6994-0223","authenticated-orcid":false,"given":"Agostino","family":"Virdis","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1922-6547","authenticated-orcid":false,"given":"Guido","family":"Grassi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Milano\u2010Bicocca Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4925-7985","authenticated-orcid":false,"given":"Fabio","family":"Angeli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Insubria Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3786-0883","authenticated-orcid":false,"given":"Marcello","family":"Arca","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo M.","family":"Barbagallo","sequence":"additional","affiliation":[{"name":"Biomedical Department of Internal Medicine and Specialistics University of Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8459-711X","authenticated-orcid":false,"given":"Michele","family":"Bombelli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Milano\u2010Bicocca Monza Italy"},{"name":"Internal Medicine, Pio XI Hospital of Desio, ASST Brianza Desio Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4044-2967","authenticated-orcid":false,"given":"Federica","family":"Cappelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7886-8027","authenticated-orcid":false,"given":"Rosario","family":"Cianci","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4367-3884","authenticated-orcid":false,"given":"Arrigo F. 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