{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:05:17Z","timestamp":1792811117456,"version":"4.5.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,9,5]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Short\u2010term effects on mitral valve (MV) anatomy after transcatheter edge\u2010to\u2010edge repair using the PASCAL system remain unknown. Precise quantification might allow for an advanced analysis of predictors for mean transmitral gradients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Consecutive patients undergoing transcatheter edge\u2010to\u2010edge repair for secondary mitral regurgitation using PASCAL or MitraClip systems were included. Quantification of short\u2010term MV changes throughout the cardiac cycle was performed using peri\u2010interventional 3\u2010dimensional MV images. Predictors for mean transmitral gradients were identified in univariable and multivariable regression analysis. Long\u2010term results were described during 1\u2010year follow\u2010up. A total of 100 patients undergoing transcatheter edge\u2010to\u2010edge repair using PASCAL (n=50) or MitraClip systems (n=50) were included. Significant reductions of anterior\u2010posterior diameter, annular circumference, and area throughout the cardiac cycle were found in both cohorts (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05 for all). Anatomic MV orifice area remained larger in the PASCAL cohort in mid (2.8\u00b11.0\u2009versus 2.4\u00b10.9\u2009cm\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.049) and late diastole (2.7\u00b11.1\u2009versus 2.2\u00b10.8\u2009cm\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.036) compared with the MitraClip cohort. Besides a device\u2010specific profile of independent predictor of mean transmitral gradients, reduction of middiastolic anatomic MV orifice area was identified as an independent predictor in both the PASCAL (\n              <jats:italic>\u03b2<\/jats:italic>\n              =\u22120.410;\n              <jats:italic>P<\/jats:italic>\n              =0.001) and MitraClip cohorts (\n              <jats:italic>\u03b2<\/jats:italic>\n              =\u22120.318;\n              <jats:italic>P<\/jats:italic>\n              =0.028). At follow\u2010up, reduction of mitral regurgitation grade to mild or less was more durable in the PASCAL cohort (90% versus 72%;\n              <jats:italic>P<\/jats:italic>\n              =0.035).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">PASCAL and MitraClip showed comparable short\u2010term effects on MV geometry. However, PASCAL might better preserve MV function and demonstrated more durable mitral regurgitation reduction during follow\u2010up. Identification of independent predictors for mean transmitral gradients might potentially help to guide device selection in the future.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.030333","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T09:27:46Z","timestamp":1693387666000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Short\u2010Term Effects of Different Transcatheter Edge\u2010to\u2010Edge Devices on Mitral Valve Geometry"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4380-4821","authenticated-orcid":false,"given":"Sebastian","family":"Rosch","sequence":"first","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luise","family":"K\u00f6sser","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Heart Center Leipzig at University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8082-6472","authenticated-orcid":false,"given":"Christian","family":"Besler","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Kister","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8616-6751","authenticated-orcid":false,"given":"Karl\u2010Patrik","family":"Kresoja","sequence":"additional","affiliation":[{"name":"Department of Cardiology Heart Center Leipzig at University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Heart Center Leipzig at University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1000-4710","authenticated-orcid":false,"given":"Mateo","family":"Marin\u2010Cuartas","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Heart Center Leipzig at University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8054-4662","authenticated-orcid":false,"given":"Massimiliano","family":"Meineri","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Heart Center Leipzig at University of Leipzig Leipzig 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