{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:10:15Z","timestamp":1787962215795,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,10,3]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patient\u2010reported outcome measures have been shown to have important prognostic value after various cardiac interventions. We assessed the association between the change in Kansas City Cardiomyopathy Questionnaire 12 (KCCQ\u201012) score after transcatheter aortic valve replacement and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We included patients who underwent transcatheter aortic valve replacement at Mayo Clinic between February 2012 to June 2022 and who completed a KCCQ\u201012 before and 30 to 45\u2009days after the procedure. Patients were categorized into 3 groups: those who experienced significant (&gt;+19 points; group 1), modest (1\u201319 points; group 2), and no (\u22640 points; group 3) improvement. A total of 1124 patients were included: 60.8% men; 97.6% White. Mean age was 79.4\u00b18.3\u2009years, baseline KCCQ\u201012 score was 53.9\u00b124.5, and median Society of Thoracic Surgeons score was 4.9% (interquartile range, 3.1\u20138.0). At 45\u2009days, the mean change in KCCQ\u201012 score was 19\u00b124 points; 46.3% (n=520) of patients had a significant improvement in their KCCQ\u201012 score, while 33.4% (n=375) and 20.4% (n=229) had modest and no improvement, respectively. Median survival was higher in group 1 (5.7\u00b10.2\u2009years) compared with groups 2 and 3 (5.1\u00b10.3 and 4.1\u00b10.4\u2009years, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Compared with patients in group 1, those in groups 2 and 3 had higher long\u2010term risk\u2010adjusted mortality (adjusted hazard ratios, 1.54 [95% CI, 1.20\u20131.96], and 2.30 [95% CI, 1.74\u20133.04], respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients who experience modest or no improvement in KCCQ\u201012 score after transcatheter aortic valve replacement have substantially higher long\u2010term mortality. Delta KCCQ\u201012 is a cost\u2010effective, efficient tool that can identify patients at increased risk of death at long\u2010term follow\u2010up post\u2010transcatheter aortic valve replacement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.030383","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:59:02Z","timestamp":1695715142000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic Value of Patient\u2010Reported Outcomes in Predicting Long\u2010Term Mortality After Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"12","author":[{"given":"Hasan S.","family":"Alarouri","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Disease Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"El Shaer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Wisconsin Hospitals &amp; Clinics Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6685-8339","authenticated-orcid":false,"given":"Alejandra Chavez","family":"Ponce","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-9143","authenticated-orcid":false,"given":"Abdulah","family":"Mahayni","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1303-6622","authenticated-orcid":false,"given":"Samian","family":"Sulaiman","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease West Virginia University Morgantown WV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2133-3106","authenticated-orcid":false,"given":"Sahar","family":"Samimi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-0959","authenticated-orcid":false,"given":"Mohamad","family":"Alkhouli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.1474"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00531-3"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.3983"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.670901"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.11.021"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.115.001958"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.970053"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.5302"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.040022"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.120.007187"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.002875"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000029"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000932"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.7156"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2021.0372"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.820472"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.11.037"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26377"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.09.027"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.068122"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.030383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:55:40Z","timestamp":1715590540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.030383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,3]]},"references-count":20,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2023,10,3]]}},"alternative-id":["10.1161\/JAHA.123.030383"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.030383","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.03.29.23287935","asserted-by":"object"}]},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,3]]},"assertion":[{"value":"2023-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e030383"}}