{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:07Z","timestamp":1787018107802,"version":"build-2736575974"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,5,21]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Abdominal obesity is associated with endothelial dysfunction and poorer vascular health. Avocado consumption improves postprandial endothelial function; however, the longer\u2010term effects remain unclear. It was hypothesized that the daily addition of 1 avocado to a habitual diet for 6\u2009months would improve flow\u2010mediated dilation (FMD) and carotid\u2013femoral pulse wave velocity in individuals with abdominal obesity (waist circumference \u226535 in for women, \u226540 in for men), compared with a habitual diet low in avocados.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      HAT (Habitual Diet and Avocado Trial) was a multicenter, randomized, controlled, parallel\u2010arm study that investigated the health effects of adding 1 avocado per day to a habitual diet in individuals with abdominal obesity. At the Pennsylvania State University, University Park study center (n=134; age, 50 \u00b1 13\u2009years; women, 78%; body mass index, 32.6 \u00b1 4.8\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), markers of vascular function were measured, including endothelial function, assessed via brachial artery flow\u2010mediated dilation, and arterial stiffness, assessed via carotid\u2013femoral pulse wave velocity. Between\u2010group differences in 6\u2010month change in flow\u2010mediated dilation and carotid\u2013femoral pulse wave velocity were assessed using independent\n                      <jats:italic>t<\/jats:italic>\n                      tests. Prespecified subgroup analyses were conducted using linear regression. No significant between\u2010group differences in flow\u2010mediated dilation (mean difference=\u22120.62% [95% CI, \u22121.70 to 0.46]) or carotid\u2013femoral pulse wave velocity (0.25\u2009m\/s [95% CI, \u22120.13 to 0.63]) were observed. Results of the subgroup analyses were consistent with the primary analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Longer\u2010term consumption of 1 avocado per day as part of a habitual diet did not improve measures of vascular function compared with a habitual diet low in avocados in individuals with abdominal obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT03528031.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.030497","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T06:32:13Z","timestamp":1715322733000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Incorporating 1 Avocado per Day Versus Habitual Diet on Vascular Function in Adults With Abdominal Obesity: An Ancillary Study of HAT, a Randomized Controlled Trial"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4078-3794","authenticated-orcid":false,"given":"Kristin M.","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences Pennsylvania State University University Park PA USA"},{"name":"Department of Psychology Wayne State University Detroit MI 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