{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:46:09Z","timestamp":1777524369258,"version":"3.51.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,10,17]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Although most individuals can adapt to a large iodine load and remain euthyroid, hypothyroidism can develop after iodine exposure. Hypothyroidism is associated with adverse cardiovascular consequences, including heart failure. This study was performed to investigate the relationships between iodine\u2010induced hypothyroidism and incident heart failure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This cohort study of the US Veterans Health Administration (1998\u20132021) included adults aged \u226518\u2009years with a serum thyroid\u2010stimulating hormone (thyrotropin) &lt;60\u2009days of iodine contrast administration, and &lt;1\u2009year of a baseline normal serum thyroid\u2010stimulating hormone. Cox proportional hazards regression ascertained risk of incident heart failure following iodine\u2010induced hypothyroidism, adjusting for age, sex, race and ethnicity, body mass index, and history of coronary heart disease, dyslipidemia, diabetes, and hypertension. Of 45\u2009470 veterans (mean\u00b1SD age, 61.1\u00b114.1\u2009years; 88% men), 3361 (7.4%) developed iodine\u2010induced hypothyroidism. Heart failure developed in 5685 (12.5%) individuals over a median follow\u2010up of 3.6\u2009years (interquartile range, 1.9\u20137.2\u2009years). Adjusted for risk factors, iodine\u2010induced hypothyroidism was associated with increased risk of heart failure, compared with those who remained euthyroid after iodine exposure (adjusted hazard ratio [HR], 1.11 [95% CI, 1.01\u20131.22]). Women were at greater risk than men (adjusted HR: women, 1.65 [95% CI, 1.13\u20132.40]; men, 1.08 [95% CI, 0.98\u20131.19];\n              <jats:italic>P<\/jats:italic>\n              for interaction, 0.02).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In the largest US study of this topic, hypothyroidism following iodine exposure was associated with an increased risk of incident heart failure, particularly in women. These findings support the need for further research to address the clinical significance of this issue, including the possible sex\u2010specific risks of incident heart failure in more diverse data sets and study populations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.030511","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T10:50:43Z","timestamp":1696935043000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Iodine\u2010Induced Hypothyroidism and Long\u2010Term Risks of Incident Heart Failure"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9614-8103","authenticated-orcid":false,"given":"Kosuke","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Social Epidemiology, Graduate School of Medicine Kyoto University Kyoto 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V.","family":"Neverova","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Veterans Affairs Greater Los Angeles Healthcare System Los Angeles CA USA"},{"name":"Division of Cardiology, Department of Medicine University of California Los Angeles David Geffen School of Medicine Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3728-1339","authenticated-orcid":false,"given":"Ramin","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Veterans Affairs Greater Los Angeles Healthcare System Los Angeles CA USA"},{"name":"Division of Cardiology, Department of Medicine University of California Los Angeles David Geffen School of Medicine Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse W.","family":"Currier","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Veterans Affairs Greater Los Angeles Healthcare System Los Angeles CA USA"},{"name":"Division of Cardiology, Department of Medicine University of California Los Angeles David Geffen School of Medicine Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad T.","family":"Bashir","sequence":"additional","affiliation":[{"name":"Research Service Veterans Affairs Greater Los Angeles Healthcare System Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8935-9332","authenticated-orcid":false,"given":"Angela M.","family":"Leung","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine Veterans Affairs Greater Los Angeles Healthcare System Los Angeles CA USA"},{"name":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine University of California Los Angeles David Geffen School of 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