{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:44:24Z","timestamp":1785570264919,"version":"3.56.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,10,17]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We aimed to evaluate the relationships between the magnitude of systolic blood pressure (SBP) reduction and achieved SBP in the acute phase of ischemic stroke onset and subsequent clinical outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">This study was a secondary analysis of CATIS (China Antihypertensive Trial in Acute Ischemic Stroke), a multicenter randomized controlled trial of 4071 patients with acute ischemic stroke. SBP reduction was defined as the proportional SBP changes from baseline to 24\u2009hours after randomization, and achieved SBP was the mean of SBP measurements at day 7. The study outcomes included functional outcome of death or major disability (modified Rankin Scale score \u22653), death,\u00a0and cardiovascular events at 3 months after recruitment. Compared with the reference group of increase or no change in SBP within the first 24 hours, the odds ratios (95% CIs) of functional outcome of death or major disability were 0.62 (0.47\u20130.83) and 0.61 (0.42\u20130.87) for the reduction of 11% to 20% and &gt;20%, respectively. Compared with participants in highest achieved SBP group (\u2265160\u2009mm\u2009Hg) at day 7, odds ratios or hazard ratios of lower achieved SBP (&lt;130\u2009mm\u2009Hg) were 0.54 (95% CI, 0.37\u20130.80) for functional outcome, and 0.36 (95% CI, 0.17\u20130.80) for death or cardiovascular events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">A moderate magnitude of SBP reduction and a lower early achieved SBP were associated with a decreased risk of poor functional outcome, death, and cardiovascular events after acute ischemic stroke. Further studies are warranted to confirm these findings.<\/jats:p>\n            <jats:p xml:lang=\"en\">\n              REGISTRATION: URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01840072.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.030692","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T11:46:14Z","timestamp":1696679174000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Magnitude of Systolic Blood Pressure Reduction and Early Achieved Blood Pressure and Clinical Outcomes After Acute Ischemic Stroke"],"prefix":"10.1161","volume":"12","author":[{"given":"Yujia","family":"Zhai","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health, 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