{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:18:14Z","timestamp":1793398694257,"version":"4.5.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,10,17]]},"abstract":"\n Background<\/jats:title>\n Limited data are available about clinical outcomes and residual mitral regurgitation (MR) after transcatheter edge\u2010to\u2010edge repair in the large Asian\u2010Pacific cohort.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n From the Optimized Catheter Valvular Intervention (OCEAN\u2010Mitral) registry, a total of 2150 patients (primary cause of 34.6%) undergoing transcatheter edge\u2010to\u2010edge repair were analyzed and classified into 3 groups according to the residual MR severity at discharge: MR 0+\/1+, 2+, and 3+\/4+. The mortality and heart failure hospitalization rates at 1 year were 12.3% and 15.0%, respectively. Both MR and symptomatic improvement were sustained at 1 year with MR \u22642+ in 94.1% of patients and New York Heart Association functional class I\/II in 95.0% of patients. Compared with residual MR 0+\/1+ (20.4%) at discharge, both residual MR 2+ (30.2%;\n P<\/jats:italic>\n \u2009<\u20090.001) and 3+\/4+ (32.4%;\n P<\/jats:italic>\n \u2009=\u20090.007) were associated with the higher incidence of death or heart failure hospitalization (adjusted hazard ratio [HR], 1.59;\n P<\/jats:italic>\n \u2009<\u20090.001, and adjusted HR, 1.73;\n P<\/jats:italic>\n \u2009=\u20090.008). New York Heart Association class III\/IV at 1 year was more common in the MR 3+\/4+ group (20.0%) than in the MR 0+\/1+ (4.6%;\n P<\/jats:italic>\n \u2009<\u20090.001) and MR 2+ (6.4%;\n P<\/jats:italic>\n \u2009<\u20090.001) groups, and the proportion of New York Heart Association class I is significantly higher in the MR 1+ group (57.8%) than in the MR 2+ group (48.3%;\n P<\/jats:italic>\n \u2009=\u20090.02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The OCEAN\u2010Mitral registry demonstrated favorable clinical outcomes and sustained MR reduction at 1 year in patients undergoing transcatheter edge\u2010to\u2010edge repair. Both residual MR 2+ and 3+\/4+ after transcatheter edge\u2010to\u2010edge repair at discharge were associated with worse clinical outcomes compared with residual MR 0+\/1+.<\/jats:p>\n <\/jats:sec>\n \n Registration Information<\/jats:title>\n \n https:\/\/upload.umin.ac.jp<\/jats:ext-link>\n . Identifier: UMIN000023653.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.123.030747","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T06:43:40Z","timestamp":1696920220000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["One\u2010Year Outcomes and Their Relationship to Residual Mitral Regurgitation After Transcatheter Edge\u2010to\u2010Edge Repair With MitraClip Device: Insights From the OCEAN\u2010Mitral Registry"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4794-7843","authenticated-orcid":false,"given":"Shunsuke","family":"Kubo","sequence":"first","affiliation":[{"name":"Department of Cardiology Kurashiki Central Hospital Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology Toyohashi Heart Center 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