{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:55:13Z","timestamp":1789599313796,"version":"build-2803163510"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,11,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Albuminuria is a known marker of mortality risk. Whether the association between albuminuria and mortality differs by demographic and comorbidity factors remains unclear. Therefore, we sought to determine whether albuminuria is differentially associated with mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study included 49\u2009640 participants from the National Health and Nutrition Examination Survey (1999\u20132018). All\u2010cause mortality through 2019 was linked from the National Death Index. Multivariable\u2010adjusted Poisson regression models were used to determine whether levels of urine albumin\u2010to\u2010creatinine ratio (ACR) were associated with mortality. Models were adjusted for demographic, socioeconomic, behavioral, and clinical factors. Mean age in the population was 46\u2009years, with 51.3% female, and 30.3% with an ACR \u226510\u2009mg\/g. Over a median follow\u2010up of 9.5\u2009years, 6813 deaths occurred. Compared with ACR &lt;10, ACR \u2265300 was associated with increased risk of mortality by 132% overall (95% CI, 2.01\u20132.68), 124% among men (95% CI, 1.84\u20132.73), 158% among women (95% CI, 2.14\u20133.11), 130% among non\u2010Hispanic White adults (95% CI: 1.89\u20132.79), 135% among non\u2010Hispanic Black adults (95% CI, 1.82\u20133.04), and 114% among Hispanic adults (95% CI, 1.55\u20132.94). Compared with ACR &lt;10, ACR \u2265300 was associated with increased risk of mortality by 148% among individuals with neither hypertension nor hypercholesterolemia (95% CI, 1.69\u20133.64), 128% among individuals with hypertension alone (95% CI, 1.86\u20132.79), and 166% among individuals with both hypertension and hypercholesterolemia (95% CI, 2.18\u20133.26).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">We found strong associations between albuminuria and mortality risk, even at mildly increased levels of albuminuria. Associations persisted across categories of sex, race or ethnicity, and comorbid conditions, with subtle differences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.030773","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T06:29:21Z","timestamp":1697610561000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Associations Between Albuminuria and Mortality Among US Adults by Demographic and Comorbidity Factors"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8563-4608","authenticated-orcid":false,"given":"Yelena","family":"Drexler","sequence":"first","affiliation":[{"name":"Katz Family Division of Nephrology and Hypertension, Department of Medicine University of Miami Miller School of Medicine FL Miami 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