{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:02:42Z","timestamp":1793142162462,"version":"4.5.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,4,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Percutaneous heart valve procedures have been increasingly performed over the past decade, yet real\u2010world mortality data on valvular heart disease (VHD) in the United States remain limited.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We queried the Centers for Disease Control and Prevention's Wide\u2010Ranging Online Data for Epidemiologic Research database among patients \u226515\u2009years old from 1999 to 2020. VHD and its subtypes were listed as the underlying cause of death. We calculated age\u2010adjusted mortality rate (AAMR) per 100\u2009000 individuals and determined overall trends by estimating the average annual percent change using the Joinpoint regression program. Subgroup analyses were performed based on demographic and geographic factors. In the 22\u2010year study, there were 446\u2009096 VHD deaths, accounting for 0.80% of all\u2010cause mortality (56\u2009014\u2009102 people) and 2.38% of the total cardiovascular mortality (18\u2009759\u2009451 people). Aortic stenosis recorded the highest mortality of VHD\u2010related death in both male (109\u2009529, 61.74%) and female (166\u2009930, 62.13%) populations. The AAMR of VHD has declined from 8.4 (95% CI, 8.2\u20138.5) to 6.6 (95% CI, 6.5\u20136.7) per 100\u2009000 population. Similar decreasing AAMR trends were also seen for the VHD subtypes. Men recorded higher AAMR for aortic stenosis and aortic regurgitation, whereas women had higher AAMR for mitral stenosis and mitral regurgitation. Mitral regurgitation had the highest change in average annual percent change in AAMR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The mortality rate of VHD among the US population has declined over the past 2 decades. This highlights the likely efficacy of increasing surveillance and advancement in the management of VHD, resulting in improved outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.030895","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T10:32:40Z","timestamp":1712572360000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Trends and Disparities in Valvular Heart Disease Mortality in the United States From 1999 to 2020"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7682-8934","authenticated-orcid":false,"given":"Min Choon","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix AZ USA"},{"name":"Department of Internal Medicine New York Medical College at Saint Michael\u2019s Medical Center Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5559-7236","authenticated-orcid":false,"given":"Yong Hao","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Pediatrics Beaumont Health Royal Oak MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boon Jian","family":"San","sequence":"additional","affiliation":[{"name":"AIMST University Bedong Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Addi","family":"Suleiman","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine New York Medical College at Saint Michael\u2019s Medical Center Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin Z.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-308X","authenticated-orcid":false,"given":"Arka","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Arizona Sarver Heart Center\/Banner University Medical Center Tucson AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5933-3537","authenticated-orcid":false,"given":"Kristen A.","family":"Sell\u2010Dottin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Mayo Clinic Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2820-6839","authenticated-orcid":false,"given":"F. 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