{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:10:23Z","timestamp":1791972623073,"version":"4.3.4"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,1,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">There are \u22485\u2009million annual dizziness visits to US emergency departments, of which vestibular strokes account for over 250\u2009000. The head impulse, nystagmus, and test of skew eye examination can accurately distinguish vestibular strokes from peripheral dizziness. However, the eye\u2010movement signs are subtle, and lack of familiarity and difficulty with recognition of abnormal eye movements are significant barriers to widespread emergency department use. To break this barrier, we sought to assess the accuracy of EyePhone, our smartphone eye\u2010tracking application, for quantifying nystagmus.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We prospectively enrolled healthy volunteers and recorded the velocity of induced nystagmus using a smartphone eye\u2010tracking application (EyePhone) and then compared the results with video oculography (VOG). Following a calibration protocol, the participants viewed optokinetic stimuli with incremental velocities (2\u201312 degrees\/s) in 4 directions. We extracted slow phase velocities from EyePhone data in each direction and compared them with the corresponding slow phase velocities obtained by the VOG. Furthermore, we calculated the area under the receiver operating characteristic curve for nystagmus detection by EyePhone. We enrolled 10 volunteers (90% men) with an average age of 30.2\u00b16 years. EyePhone\u2010recorded slow phase velocities highly correlated with the VOG recordings (r=0.98 for horizontal and r=0.94 for vertical). The calibration significantly increased the slope of linear regression for horizontal and vertical slow phase velocities. Evaluating the EyePhone's performance using VOG data with a 2 degrees\/s threshold showed an area under the receiver operating characteristic curve of 0.87 for horizontal and vertical nystagmus detection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">We demonstrated that EyePhone could accurately detect and quantify optokinetic nystagmus, similar to the VOG goggles.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.030927","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T10:12:33Z","timestamp":1705399953000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Quantifying Induced Nystagmus Using a Smartphone Eye Tracking Application (EyePhone)"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5884-2126","authenticated-orcid":false,"given":"Pouya B.","family":"Bastani","sequence":"first","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Armstrong Institute Center for Diagnostic Excellence Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4312-9432","authenticated-orcid":false,"given":"Hector","family":"Rieiro","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Armstrong Institute Center for Diagnostic Excellence Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shervin","family":"Badihian","sequence":"additional","affiliation":[{"name":"Armstrong Institute Center for Diagnostic Excellence Baltimore MD USA"},{"name":"Neurological Institute, Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9789-8392","authenticated-orcid":false,"given":"Jorge","family":"Otero\u2010Millan","sequence":"additional","affiliation":[{"name":"Herbert Wertheim School of Optometry and Vision Science University of California Berkeley CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Armstrong Institute Center for Diagnostic Excellence Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Neurology, NYU Langone Health New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2789-4115","authenticated-orcid":false,"given":"David","family":"Newman\u2010Toker","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Armstrong Institute Center for Diagnostic Excellence Baltimore MD USA"},{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Armstrong Institute Center for Diagnostic Excellence Baltimore MD USA"},{"name":"Department of Biostatistics Johns Hopkins University Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4563-4018","authenticated-orcid":false,"given":"Ali","family":"Saber Tehrani","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.05.023"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4065\/83.7.765"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","unstructured":"Newman\u2010Toker DE Peterson SM Badihian S Hassoon A Nassery N Parizadeh D Wilson LM Jia Y Omron R Tharmarajah S et\u00a0al. 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VertiGo\u2010App\u2013Smartphone\u2010based video nystagmography using artificial intelligence. Laryngo Rhino Otol. 2022;101:243\u2013244.","journal-title":"Laryngo Rhino Otol"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2022.01.087"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000511287"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238148"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2004.11.009"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00247608"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016487909137147"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160614"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.789581"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.030927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:34:36Z","timestamp":1715603676000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.030927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,16]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1,16]]}},"alternative-id":["10.1161\/JAHA.123.030927"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.030927","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,16]]},"assertion":[{"value":"2023-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e030927"}}