{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:50:50Z","timestamp":1783633850544,"version":"3.55.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,3,5]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The effects of pharmacological therapy on cardiogenic shock (CS) survivors have not been extensively studied. Thus, this study investigated the association between guideline\u2010directed heart failure (HF) medical therapy (GDMT) and one\u2010year survival rate in patients who are post\u2010CS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              FRENSHOCK (French Observatory on the Management of Cardiogenic Shock in 2016) registry was a prospective multicenter observational survey, conducted in metropolitan French intensive care units and intensive cardiac care units. Of 772 patients, 535 patients were enrolled in the present analysis following the exclusion of 217 in\u2010hospital deaths and 20 patients with missing medical records. Patients with triple GDMT (beta\u2010blockers, renin\u2010angiotensin system inhibitors, and mineralocorticoid receptor antagonists) at discharge (n=112) were likely to have lower left ventricular ejection fraction on admission and at discharge compared with those without triple GDMT (n=423) (22% versus 28%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 and 29% versus 37%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001, respectively). In the overall cohort, the one\u2010year mortality rate was 23%. Triple GDMT prescription was significantly associated with a lower one\u2010year all\u2010cause mortality compared with non\u2010triple GDMT (adjusted hazard ratio 0.44 [95% CI, 0.19\u20130.80];\n              <jats:italic>P<\/jats:italic>\n              =0.007). Similarly, 2:1 propensity score matching and inverse probability treatment weighting based on the propensity score demonstrated a lower incidence of one\u2010year mortality in the triple GDMT group. As the number of HF drugs increased, a stepwise decrease in mortality was observed (log rank;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In survivors of CS, the one\u2010year mortality rate was significantly lower in those with triple GDMT. Therefore, this study suggests that intensive HF therapy should be considered in patients following CS.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.030975","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T10:46:48Z","timestamp":1708685208000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Optimal Heart Failure Medical Therapy and Mortality in Survivors of Cardiogenic Shock: Insights From the FRENSHOCK Registry"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3722-2921","authenticated-orcid":false,"given":"Kensuke","family":"Matsushita","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Strasbourg, P\u00f4le d\u2019Activit\u00e9 M\u00e9dico\u2010Chirurgicale Cardio\u2010Vasculaire, Nouvel H\u00f4pital Civil Centre Hospitalier Universitaire Strasbourg France"},{"name":"UMR1260 INSERM, Nanom\u00e9decine R\u00e9g\u00e9n\u00e9rative Universit\u00e9 de Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9180-9128","authenticated-orcid":false,"given":"Cl\u00e9ment","family":"Delmas","sequence":"additional","affiliation":[{"name":"Intensive Cardiac Care Unit Rangueil University Hospital\/Institute of Metabolic and Cardiovascular Diseases (I2MC), UMR\u20101048, INSERM Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-1466","authenticated-orcid":false,"given":"Benjamin","family":"Marchandot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Strasbourg, P\u00f4le d\u2019Activit\u00e9 M\u00e9dico\u2010Chirurgicale Cardio\u2010Vasculaire, Nouvel H\u00f4pital Civil Centre Hospitalier Universitaire Strasbourg 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