{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:24:40Z","timestamp":1788452680598,"version":"build-2803163510"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,3,19]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Recurrence after atrial fibrillation (AF) ablation remains common. We evaluated the association between recurrence and levels of biomarkers of cardiac remodeling, and their ability to improve recurrence prediction when added to a clinical prediction model.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Blood samples collected before de novo catheter ablation were analyzed. Levels of bone morphogenetic protein\u201010, angiopoietin\u20102, fibroblast growth factor\u201023, insulin\u2010like growth factor\u2010binding protein\u20107, myosin\u2010binding protein C3, growth differentiation factor\u201015, interleukin\u20106, N\u2010terminal pro\u2010brain natriuretic peptide, and high\u2010sensitivity troponin T were measured. Recurrence was defined as \u226530\u2009seconds of an atrial arrhythmia 3 to 12\u2009months postablation. Multivariable logistic regression was performed using biomarker levels along with clinical covariates: APPLE score (Age &gt;65 years, Persistent AF, imPaired eGFR [&lt;60 ml\/min\/1.73m\n              <jats:sup>2<\/jats:sup>\n              ], LA diameter \u226543 mm, EF &lt;50%; which includes age, left atrial diameter, left ventricular ejection fraction, persistent atrial fibrillation, and estimated glomerular filtration rate), preablation rhythm, sex, height, body mass index, presence of an implanted continuous monitor, year of ablation, and additional linear ablation. A total of 1873 participants were included. A multivariable logistic regression showed an association between recurrence and levels of angiopoietin\u20102 (odds ratio, 1.08 [95% CI, 1.02\u20131.15],\n              <jats:italic>P<\/jats:italic>\n              =0.007) and interleukin\u20106 (odds ratio, 1.02 [95% CI, 1.003\u20131.03];\n              <jats:italic>P<\/jats:italic>\n              =0.02). The area under the receiver operating characteristic curve of a model that only contained clinical predictors was 0.711. The addition of any of the 9 studied biomarkers to the predictive model did not result in a statistically significant improvement in the area under the receiver operating characteristic curve.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Higher angiopoietin\u20102 and interleukin\u20106 levels were associated with recurrence after atrial fibrillation ablation in multivariable modeling. However, the addition of biomarkers to a clinical prediction model did not significantly improve recurrence prediction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.031029","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T02:08:26Z","timestamp":1710295706000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Recurrence After Atrial Fibrillation Ablation and Investigational Biomarkers of Cardiac Remodeling"],"prefix":"10.1161","volume":"13","author":[{"given":"Majd A.","family":"El\u2010Harasis","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Quintana","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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