{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:48:44Z","timestamp":1791910124515,"version":"4.3.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,11,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with pulmonary atresia or critical pulmonary stenosis with intact ventricular septum (PA\/IVS) and biventricular circulation may require pulmonary valve replacement (PVR). Right ventricular (RV) remodeling after PVR is well described in tetralogy of Fallot (TOF); we sought to investigate RV changes in PA\/IVS using cardiac magnetic resonance imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A retrospective cohort of patients with PA\/IVS who underwent PVR at Boston Children's Hospital from 1995 to 2021 with cardiac magnetic resonance imaging before and after PVR was matched 1:3 with patients with TOF by age at PVR. Median regression modeling was performed with post\u2010PVR indexed RV end\u2010diastolic volume as the primary outcome. A total of 20 patients with PA\/IVS (cases) were matched with 60 patients with TOF (controls), with median age at PVR of 14\u2009years. Pre\u2010PVR indexed RV end\u2010diastolic volume was similar between groups; cases had higher RV ejection fraction (51.4% versus 48.6%;\n                      <jats:italic>P<\/jats:italic>\n                      =0.03). Pre\u2010PVR RV free wall and left ventricular (LV) longitudinal strain were similar, although LV midcavity circumferential strain was decreased in cases (\u221215.6 versus \u221217.1;\n                      <jats:italic>P<\/jats:italic>\n                      =0.001). At a median of 2\u2009years after PVR, indexed RV end\u2010diastolic volume was similarly reduced; cases continued to have higher RV ejection fraction (52.3% versus 46.9%;\n                      <jats:italic>P<\/jats:italic>\n                      =0.007) with less reduction in RV mass (\u03944.5 versus 9.6 g\/m\n                      <jats:sup>2<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      =0.004). Post\u2010PVR, RV and LV longitudinal strain remained unchanged, and LV circumferential strain was similar, although lower in cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Compared with patients with TOF, patients with PA\/IVS demonstrate similar RV remodeling after PVR, with lower reduction in RV mass and comparatively higher RV ejection fraction. Although no differences were detected in peak systolic RV or LV strain values, further investigation of diastolic parameters is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.031090","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T06:30:21Z","timestamp":1699252221000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Right Heart Remodeling After Pulmonary Valve Replacement in Patients With Pulmonary Atresia or Critical Stenosis With Intact Ventricular Septum"],"prefix":"10.1161","volume":"12","author":[{"given":"Margaret","family":"Irwin","sequence":"first","affiliation":[{"name":"Harvard Medical School Boston MA"},{"name":"Department of Cardiology, Boston Children\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA"},{"name":"Department of Cardiology, Boston Children\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3037-9202","authenticated-orcid":false,"given":"Geoffrey","family":"Binney","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA"},{"name":"Department of Cardiology, Boston Children\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2619-1389","authenticated-orcid":false,"given":"Stuart","family":"Lipsitz","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA"},{"name":"Department of Cardiology, Boston Children\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4227-8823","authenticated-orcid":false,"given":"Sunil J.","family":"Ghelani","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA"},{"name":"Department of Cardiology, Boston Children\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Harrild","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA"},{"name":"Department of Cardiology, Boston Children\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Baird","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA"},{"name":"Department of Cardiovascular Surgery, Boston Children\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3538-1865","authenticated-orcid":false,"given":"Tal","family":"Geva","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA"},{"name":"Department of Cardiology, Boston Children\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8406-5957","authenticated-orcid":false,"given":"David W.","family":"Brown","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA"},{"name":"Department of Cardiology, Boston Children\u2019s Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1089253218756757"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.04.003"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000818"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-016-1506-4"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.004428"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-017-1706-6"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/2150135117701407"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-018-2009-2"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezw124"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-018-0460-0"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.pcsu.2006.02.009"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-13-9"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2013.11.009"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21094"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1981.10477633"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9876.2011.01028.x"},{"key":"e_1_3_1_18_2","first-page":"463","article-title":"Quantile regression methods for longitudinal data with drop\u2010outs: application to cd4 cell counts of patients infected with the human immunodeficiency virus","volume":"46","author":"Lipsitz SR","year":"1997","unstructured":"Lipsitz SR, Fitzmaurice GM, Molenberghs G, Zhao LP. Quantile regression methods for longitudinal data with drop\u2010outs: application to cd4 cell counts of patients infected with the human immunodeficiency virus. J Royal Stat Soc. 1997;46:463\u2013476.","journal-title":"J Royal Stat Soc"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxab035"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00528.x"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/096228029900800102"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.09.024"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013654"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.02.031"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-023-00928-x"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.02.067"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjco.2020.02.006"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11206186"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2020.01.10"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.031090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:17:01Z","timestamp":1715588221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.031090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,7]]},"references-count":28,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2023,11,7]]}},"alternative-id":["10.1161\/JAHA.123.031090"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.031090","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.05.19.23290256","asserted-by":"object"}]},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,7]]},"assertion":[{"value":"2023-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e031090"}}