{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:23:56Z","timestamp":1792268636149,"version":"4.4.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Ferroptosis, an iron\u2010dependent form of regulated cell death, is a major cell death mode in myocardial ischemia reperfusion (I\/R) injury, along with mitochondrial permeability transition\u2010driven necrosis, which is inhibited by cyclosporine A (CsA). However, therapeutics targeting ferroptosis during myocardial I\/R injury have not yet been developed. Hence, we aimed to investigate the therapeutic efficacy of deferasirox, an iron chelator, against hypoxia\/reoxygenation\u2010induced ferroptosis in cultured cardiomyocytes and myocardial I\/R injury.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">The effects of deferasirox on hypoxia\/reoxygenation\u2010induced iron overload in the endoplasmic reticulum, lipid peroxidation, and ferroptosis were examined in cultured cardiomyocytes. In a mouse model of I\/R injury, the infarct size and adverse cardiac remodeling were examined after treatment with deferasirox, CsA, or both in combination. Deferasirox suppressed hypoxia\u2010 or hypoxia\/reoxygenation\u2010induced iron overload in the endoplasmic reticulum, lipid peroxidation, and ferroptosis in cultured cardiomyocytes. Deferasirox treatment reduced iron levels in the endoplasmic reticulum and prevented increases in lipid peroxidation and ferroptosis in the I\/R\u2010injured myocardium 24\u2009hours after I\/R. Deferasirox and CsA independently reduced the infarct size after I\/R injury to a similar degree, and combination therapy with deferasirox and CsA synergistically reduced the infarct size (infarct area\/area at risk; control treatment: 64\u00b12%; deferasirox treatment: 48\u00b13%; CsA treatment: 48\u00b14%; deferasirox+CsA treatment: 37\u00b13%), thereby ameliorating adverse cardiac remodeling on day 14 after I\/R.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Combination therapy with deferasirox and CsA may be a clinically feasible and effective therapeutic approach for limiting I\/R injury and ameliorating adverse cardiac remodeling after myocardial infarction.<\/jats:p>\n          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