{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:52:06Z","timestamp":1788997926548,"version":"build-2803163510"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,11,21]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Psoriasis is a chronic inflammatory condition associated with coronary artery disease risk. Uptake of oxidized low\u2010density lipoprotein by the lectin\u2010like low\u2010density lipoprotein receptor\u20101 triggers release of the soluble extracellular domain of the receptor (sLOX\u20101). We sought to characterize the relationship between sLOX\u20101, inflammation, and coronary plaque progression in psoriasis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 327 patients with psoriasis had serum sLOX\u20101 levels measured at baseline by an ELISA\u2010based assay. Stratification by high\u2010sensitivity C\u2010reactive protein \u22654.0\u2009mg\/L (quartile 4), identified 81 participants who had coronary plaque phenotyping at baseline and were followed longitudinally by coronary computed tomography angiography. Subjects within high\u2010sensitivity C\u2010reactive protein quartile 4 were middle\u2010aged (51.47\u00b112.62\u2009years), predominantly men (54.3%) with moderate psoriasis disease severity (6.60 [interquartile range, 3.30\u201313.40]). In the study cohort, participants with sLOX\u20101 above the median displayed increased vulnerable coronary plaque features. At baseline, sLOX\u20101 was associated with total burden (rho=0.296;\n              <jats:italic>P<\/jats:italic>\n              =0.01), noncalcified burden (rho=0.286;\n              <jats:italic>P<\/jats:italic>\n              =0.02), fibro\u2010fatty burden (rho=0.346;\n              <jats:italic>P<\/jats:italic>\n              =0.004), and necrotic burden (rho=0.394;\n              <jats:italic>P<\/jats:italic>\n              =0.002). A strong relationship between sLOX\u20101, noncalcified burden (\n              <jats:italic>\u03b2<\/jats:italic>\n              =0.19;\n              <jats:italic>P<\/jats:italic>\n              =0.03), and fibro\u2010fatty burden (\n              <jats:italic>\u03b2<\/jats:italic>\n              =0.29;\n              <jats:italic>P<\/jats:italic>\n              =0.003) was found in fully adjusted models at baseline and 1\u2010 and 4\u2010year follow\u2010up. Finally, coronary plaque features progressed over 1\u2009year regardless of biologic or systemic treatment in subjects with high sLOX\u20101.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients with psoriasis with both high sLOX\u20101 and high\u2010sensitivity C\u2010reactive protein levels have increased coronary plaque burden associated with atherosclerotic plaque progression independent of biologic and systemic treatment. Thus, sLOX\u20101 might be considered as a promising marker in coronary artery disease risk estimation beyond traditional risk factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01778569.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.031227","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T10:21:49Z","timestamp":1700475709000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Relationship of Soluble Lectin\u2010Like Low\u2010Density Lipoprotein Receptor\u20101 (sLOX\u20101) With Inflammation and Coronary Plaque Progression in Psoriasis"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9128-6160","authenticated-orcid":false,"given":"Elizabeth M.","family":"Florida","sequence":"first","affiliation":[{"name":"Section of Inflammation and Cardiometabolic Diseases National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-1346","authenticated-orcid":false,"given":"Haiou","family":"Li","sequence":"additional","affiliation":[{"name":"Section of Inflammation and Cardiometabolic Diseases National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9705-0746","authenticated-orcid":false,"given":"Christin G.","family":"Hong","sequence":"additional","affiliation":[{"name":"Section of Inflammation and Cardiometabolic Diseases National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6980-8433","authenticated-orcid":false,"given":"Emily L.","family":"Ongstad","sequence":"additional","affiliation":[{"name":"Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal, and Metabolism (CVRM), BioPharmaceuticals R&amp;D, AstraZeneca Gaithersburg MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2391-4158","authenticated-orcid":false,"given":"Ranjitha","family":"Gaddipati","sequence":"additional","affiliation":[{"name":"Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal, and Metabolism (CVRM), BioPharmaceuticals R&amp;D, AstraZeneca Gaithersburg MD 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