{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T01:15:24Z","timestamp":1788743724370,"version":"build-2803163510"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,11,21]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Regional wall motion abnormalities (WMAs) after myocardial infarction are associated with adverse remodeling and increased mortality in the short to medium term. Their long\u2010term prognostic impact is less well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Via the National Echo Database of Australia (2000\u20132019), we identified normal wall motion versus WMA for each left ventricular wall among 492\u2009338 individuals aged 61.9\u00b117.9\u2009years. The wall motion score index was also calculated. We then examined actual 1\u2010 and 5\u2010year mortality, plus adjusted risk of long\u2010term mortality according to WMA status. Overall, 39\u2009346\/255\u2009697 men (15.4%) and 17\u2009834\/236\u2009641 women (7.5%) had a\u00a0WMA. The likelihood of a WMA was associated with increasing age and greater systolic\/diastolic dysfunction. A defect in the inferior versus anterior wall was the most and least common WMA in men (8.0% and 2.5%) and women (3.3% and 1.1%), respectively. Any WMA increased 5\u2010year mortality from 17.5% to 29.7% in men and from 14.9% to 30.8% in women. Known myocardial infarction (hazard ratio [HR], 0.86 [95% CI, 0.80\u20130.93]) or revascularization (HR, 0.87 [95% CI, 0.82\u20130.92]) was independently associated with a better prognosis, whereas men (1.22\u2010fold increase) and those with greater systolic\/diastolic dysfunction had a worse prognosis. Among those with any WMA, apical (HR, 1.08 [95% CI, 1.02\u20131.13]) or inferior (HR, 1.09 [95% CI, 1.04\u20131.15]) akinesis, dyskinesis or aneurysm, or a wall motion score index &gt;3.0 conveyed the worst prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In a large real\u2010world clinical cohort, twice as many men as women have a WMA, with inferior WMA the most common. Any WMA confers a poor prognosis, especially inferoapical akinesis\/dyskinesis\/aneurysm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.031243","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T05:17:13Z","timestamp":1699593433000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Pattern and Prognostic Impact of Regional Wall Motion Abnormalities in 255\u2009697 Men and 236\u2009641 Women Investigated with Echocardiography"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4492-1103","authenticated-orcid":false,"given":"David","family":"Playford","sequence":"first","affiliation":[{"name":"Institute for Health Research, University of Notre Dame Fremantle Western Australia Australia"},{"name":"School of Medicine The University of Notre Dame Fremantle Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-8998","authenticated-orcid":false,"given":"Simon","family":"Stewart","sequence":"additional","affiliation":[{"name":"Institute for Health Research, University of Notre Dame Fremantle Western Australia Australia"},{"name":"School of Medicine, Dentistry and Nursing University of Glasgow Glasgow United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0240-4386","authenticated-orcid":false,"given":"Sarah Ann","family":"Harris","sequence":"additional","affiliation":[{"name":"Institute for Health Research, University of Notre Dame Fremantle Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3836-8145","authenticated-orcid":false,"given":"Yih\u2010Kai","family":"Chan","sequence":"additional","affiliation":[{"name":"Mary MacKillop Institute for Health Research, The Australian Catholic University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6800-7119","authenticated-orcid":false,"given":"Geoff","family":"Strange","sequence":"additional","affiliation":[{"name":"Institute for Health Research, University of Notre Dame Fremantle Western Australia Australia"},{"name":"Heart Research Institute Sydney New South Wales Australia"},{"name":"Department of Cardiology Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32203-7"},{"key":"e_1_3_2_3_2","volume-title":"Deaths in Australia","year":"2022","unstructured":"Deaths in Australia. 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