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We hypothesize that rituximab, a B cell\u2010depleting chemotherapeutic, will deplete maternal B cells in reduced uterine perfusion pressure (RUPP) rats without worsening the effect of placental ischemia on pup growth and survival.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">To test this hypothesis, the RUPP procedure was performed, and rituximab was continuously infused via miniosmotic pump. Maternal blood and tissues were collected. A separate group of dams were allowed to deliver, pup weights were recorded, and at 4\u2009months of age, tissues were collected from offspring. Immune cells were measured via flow cytometry, and AT1\u2010AA was quantified using a contraction bioassay. Blood pressure increased in RUPP rats and was normalized with rituximab treatment. RUPP offspring also had increased circulating B cells, cytolytic natural killer cells, and increased circulating AT1\u2010AA, which were normalized with maternal rituximab treatment. This is the first study to analyze the AT1\u2010AA in RUPP offspring, which was normalized with rituximab.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Our findings indicate that perinatal rituximab lowers maternal mean arterial pressure in RUPP rats and improves birth weight, circulating AT1\u2010AA, and circulating natural killer cells, indicating that rituximab improves adverse fetal outcomes in response to placental ischemia.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.031417","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T11:28:21Z","timestamp":1707910101000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["AT1\u2010AA Is Produced in Offspring in Response to Placental Ischemia and Is Lowered by B\u2010Cell Depletion Without Compromising 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