{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:43:12Z","timestamp":1793256192987,"version":"4.5.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,11,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Natriuretic peptides have been recommended as biomarkers for the diagnosis and prognosis of patients with heart failure and are often elevated in the setting of acute kidney injury. We sought to demonstrate the associations between increased baseline NT\u2010proBNP (N\u2010terminal pro\u2010B\u2010type natriuretic peptide) and adverse renal outcomes in patients with moderate\u2010to\u2010severe acute kidney injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">We reviewed electronic medical records of consecutive patients with acute kidney injury stage 2 and 3 admitted to the Cleveland Clinic between September 2011 and December 2021. Patients with NT\u2010proBNP levels collected before renal consultation or dialysis initiation were included. Adverse renal outcomes included dialysis requirement and dialysis dependence defined as patients undergoing dialysis within 72\u2009hours before hospital discharge or in\u2010hospital mortality. In our study cohort (n=3811), 2521 (66%) patients underwent dialysis, 1619 (42%) patients became dialysis dependent, and 1325 (35%) patients had in\u2010hospital mortality. After adjusting for cardiorenal risk factors, compared with the lowest quartile, the highest quartile of NT\u2010proBNP (\u226518\u2009215\u2009pg\/mL) was associated with increased likelihood of dialysis requirement (adjusted odds ratio [OR], 2.36 [95% CI, 1.87\u20132.99]), dialysis dependence (adjusted OR, 1.89 [95% CI, 2.53\u20131.34]), and in\u2010hospital mortality (adjusted OR, 1.34 [95% CI, 1.01\u20131.34]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Increased NT\u2010proBNP was associated with an increased risk of dialysis requirement, becoming dialysis dependent, and in\u2010hospital mortality in patients with moderate\u2010to\u2010severe acute kidney injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.031453","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T10:08:22Z","timestamp":1698401302000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Prognostic Value of Natriuretic Peptide Levels for Adverse Renal Outcomes in Patients With Moderate to Severe Acute Kidney Injury With or Without Heart Failure"],"prefix":"10.1161","volume":"12","author":[{"given":"Thanat","family":"Chaikijurajai","sequence":"first","affiliation":[{"name":"Kaufman Center for Heart Failure Treatment and Recovery Heart Vascular and Thoracic Institute, Cleveland Clinic Cleveland OH"},{"name":"Department of Medicine University of Minnesota Medical School Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1358-7835","authenticated-orcid":false,"given":"Sevag","family":"Demirjian","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute, Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8335-735X","authenticated-orcid":false,"given":"W. H. Wilson","family":"Tang","sequence":"additional","affiliation":[{"name":"Kaufman Center for Heart Failure Treatment and Recovery Heart Vascular and Thoracic Institute, Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001063"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp099"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1674-5"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.12.017"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc6916"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.159"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr470"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2012.64"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2021.08.015"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.029686"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001495"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvaa288"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000001473"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000500423"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2015.10.015"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000501388"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2013.823870"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-12-57"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-5299.2007.06478.x"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2004040331"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.1751"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.031453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:18:36Z","timestamp":1715588316000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.031453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,7]]},"references-count":23,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2023,11,7]]}},"alternative-id":["10.1161\/JAHA.123.031453"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.031453","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,7]]},"assertion":[{"value":"2023-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e031453"}}