{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:01:02Z","timestamp":1790402462494,"version":"4.1.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,4,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Despite significant cardiac involvement in sarcoidosis, real\u2010world data on death due to cardiovascular disease among patients with sarcoidosis is not well established.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We queried the Centers for Disease Control and Prevention's Wide\u2010Ranging Online Data for Epidemiologic Research database for data on patients with sarcoidosis aged \u226525\u2009years from 1999 to 2020. Diseases of the circulatory system except ischemic heart disease were listed as the underlying cause of death, and sarcoidosis was stated as a contributing cause of death. We calculated age\u2010adjusted mortality rate (AAMR) per 1 million individuals and determined the trends over time by estimating the annual percentage change using the Joinpoint Regression Program. Subgroup analyses were performed on the basis of demographic and geographic factors. In the 22\u2010year study period, 3301 cardiovascular deaths with comorbid sarcoidosis were identified. The AAMR from cardiovascular deaths with comorbid sarcoidosis increased from 0.53 (95% CI, 0.43\u20130.65) per 1 million individuals in 1999 to 0.87 (95% CI, 0.75\u20130.98) per 1\u2009million individuals in 2020. Overall, women recorded a higher AAMR compared with men (0.77 [95% CI, 0.74\u20130.81] versus 0.58 [95% CI, 0.55\u20130.62]). People with Black ancestry had higher AAMR than people with White ancestry (3.23 [95% CI, 3.07\u20133.39] versus 0.39 [95% CI, 0.37\u20130.41]). A higher percentage of death was seen in the age groups of 55 to 64\u2009years in men (23.11%) and women (21.81%), respectively. In terms of US census regions, the South region has the highest AAMR from cardiovascular deaths with comorbid sarcoidosis compared with other regions (0.78 [95% CI, 0.74\u20130.82]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The increase of AAMR from cardiovascular deaths with comorbid sarcoidosis and higher cardiovascular mortality rates among adults aged 55 to 64\u2009years highlight the importance of early screening for cardiovascular diseases among patients with sarcoidosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.031484","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T11:47:43Z","timestamp":1711540063000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Trends and Disparities in Cardiovascular Death in Sarcoidosis: A Population\u2010Based Retrospective Study in the United States From 1999 to 2020"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7682-8934","authenticated-orcid":false,"given":"Min Choon","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine New York Medical College at Saint Michael\u2019s Medical Center Newark NJ USA"},{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5559-7236","authenticated-orcid":false,"given":"Yong Hao","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Pediatrics Beaumont Health Royal Oak MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noreen","family":"Mirza","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine New York Medical College at Saint Michael\u2019s Medical Center Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8674-2287","authenticated-orcid":false,"given":"Boon Jian","family":"San","sequence":"additional","affiliation":[{"name":"AIMST University Kedah Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1083-8259","authenticated-orcid":false,"given":"Jian Liang","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hospital of the University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2823-9243","authenticated-orcid":false,"given":"Justin Z.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9117-2823","authenticated-orcid":false,"given":"Joanne K.","family":"Mazzarelli","sequence":"additional","affiliation":[{"name":"Department of Medicine Cooper University Health System\/Cooper Medical School of Rowan University Camden NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-6161","authenticated-orcid":false,"given":"Andrea M.","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Medicine Cooper University Health System\/Cooper Medical School of Rowan University Camden NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009096"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201511-760OC"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025479"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00444-2019"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-020-01191-x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1262211"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.58.6.1204"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-195202000-00001"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.605"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0238391"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2016.12.014"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.03.043"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020163"},{"key":"e_1_3_1_15_2","unstructured":"Multiple cause of death 1999\u20132020. 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