{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:10:16Z","timestamp":1788246616673,"version":"build-2803163510"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,2,6]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Lower hippocampal volume is associated with late\u2010life cognitive decline and is an important, but nonspecific marker for clinical Alzheimer's dementia. Cerebrovascular disease may also be associated with hippocampal volume. Here we study the role of intracranial large vessel disease (atherosclerosis) in association with hippocampal volume and the potential role of age, average late\u2010life blood pressure across all visits, and other factors (sex, apolipoprotein \u03b54 [\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54], and diabetes).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Data came from 765 community\u2010based older people (91\u2009years old on average at death; 72% women), from 2 ongoing clinical\u2010pathologic cohort studies. Participants completed baseline assessment, annual standardized blood pressure measurements, vascular risk assessment for diabetes, and blood draws to determine\n                      <jats:italic>APOE<\/jats:italic>\n                      genotype, and at death, brains were removed and underwent ex\u00a0vivo magnetic resonance imaging and neuropathologic evaluation for atherosclerosis pathology and other cerebrovascular and neurodegenerative pathologies. Linear regression models examined the association of atherosclerosis and hippocampal to hemisphere volume ratio and whether age at death, blood pressure, and other factors modified associations. In linear regression models adjusted for demographics and neurodegenerative and other cerebrovascular pathologies, atherosclerosis severity was associated with a lower hippocampal to hemisphere volume ratio. In separate models, we found the effect of atherosclerosis on the ratio of hippocampal to hemisphere volume was attenuated among advanced age at death or having higher systolic blood pressure (interaction terms\n                      <jats:italic>P<\/jats:italic>\n                      \u22640.03). We did not find confounding or interactions with sex, diabetes, or\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Atherosclerosis severity is associated with lower hippocampal volume, independent of neurodegenerative and other cerebrovascular pathologies. Higher systolic blood pressures and advanced age attenuate associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.031551","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T06:36:11Z","timestamp":1705646171000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Atherosclerosis and Hippocampal Volumes in Older Adults: The Role of Age and Blood Pressure"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1911-8482","authenticated-orcid":false,"given":"Alifiya","family":"Kapasi","sequence":"first","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center Rush University Medical Center Chicago IL"},{"name":"Department of Pathology (Neuropathology) Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-344X","authenticated-orcid":false,"given":"Ana W.","family":"Capuano","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center Rush University Medical Center Chicago IL"},{"name":"Department of Neurological Sciences Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6130-5543","authenticated-orcid":false,"given":"Melissa","family":"Lamar","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center Rush University Medical Center Chicago IL"},{"name":"Department of Psychiatry and Behavioral Sciences Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-1665","authenticated-orcid":false,"given":"Sue E.","family":"Leurgans","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center Rush University Medical Center Chicago IL"},{"name":"Department of Neurological Sciences Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2262-890X","authenticated-orcid":false,"given":"Arnold M.","family":"Evia","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3689-554X","authenticated-orcid":false,"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center Rush University Medical Center Chicago IL"},{"name":"Department of Neurological Sciences Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9705-597X","authenticated-orcid":false,"given":"Konstantinos","family":"Arfanakis","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center Rush University Medical Center Chicago IL"},{"name":"Department of Biomedical Engineering Illinois Institute of Technology Chicago IL"},{"name":"Department of Diagnostic Radiology Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-1752","authenticated-orcid":false,"given":"Julie A.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center Rush University Medical Center Chicago IL"},{"name":"Department of Pathology (Neuropathology) Rush University Medical Center Chicago IL"},{"name":"Department of Neurological Sciences Rush University Medical Center Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2342-9-17"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.12.036"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12009"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00021"},{"issue":"474","key":"e_1_3_2_6_2","first-page":"485.e4","article-title":"Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease","volume":"7","author":"Jack CR","year":"2011","unstructured":"Jack CR Jr, Barkhof F, Bernstein MA, Cantillon M, Cole PE, Decarli C, Dubois B, Duchesne S, Fox NC, Frisoni GB, et\u00a0al. 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