{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:53:00Z","timestamp":1753887180623,"version":"3.41.2"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Despite the increasing long\u2010term survival after out\u2010of\u2010hospital cardiac arrest (OHCA), the risk of subsequent acute myocardial infarction (AMI) remains poorly understood. We aimed to determine the incidence, predictors, and long\u2010term outcomes of AMI among survivors of OHCA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">We assembled a retrospective cohort of 882 patients with OHCA who survived to 30\u2009days or discharge from the hospital between 2010 and 2019. Survivors of OHCA had an increased risk of subsequent AMI, defined as AMI occurring 30\u2009days after index OHCA or following discharge from the hospital after OHCA, compared with the general population when matched for age and sex (standardized incidence ratio, 4.64 [95% CI, 3.52\u20136.01]). Age\u2010specific risks of subsequent AMI for men (standardized incidence ratio, 3.29 [95% CI, 2.39\u20134.42]) and women (standardized incidence ratio, 6.15 [95% CI, 3.27\u201310.52]) were significantly increased. A total of 7.2%, 8.3%, and 14.3% of survivors of OHCA had a subsequent AMI at 3\u2009years, 5\u2009years, and end of follow\u2010up, respectively. Age at OHCA (hazard ratio [HR], 1.04 [95% CI, 1.02\u20131.06]) and past medical history of prior AMI, defined as any AMI preceding or during the index OHCA event (HR, 1.84 [95% CI, 1.05\u20133.22]), were associated with subsequent AMI, while an initial shockable rhythm was not (HR, 1.00 [95% CI, 0.52\u20131.94]). Survivors of OHCA with subsequent AMI had a higher risk of death (HR, 1.58 [95% CI, 1.12\u20132.22]) than those without.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Survivors of OHCA are at an increased risk of subsequent AMI compared with the general population. Prior AMI, but not an initial shockable rhythm, increases this risk, while subsequent AMI predicts death. Preventive measures for AMI including cardiovascular risk factor control and revascularization may thus improve outcomes in selected patients with cardiac pathogenesis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.031716","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T10:24:10Z","timestamp":1703845450000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence and Long\u2010Term Outcomes of Acute Myocardial Infarction Among Survivors of Out\u2010of\u2010Hospital Cardiac Arrest"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4338-3876","authenticated-orcid":false,"given":"Andrew Fu Wah","family":"Ho","sequence":"first","affiliation":[{"name":"Pre\u2010Hospital and Emergency Research Centre, Health Services &amp; Systems Research, Duke\u2010NUS Medical School Singapore"},{"name":"Department of Emergency Medicine Singapore General Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3976-0088","authenticated-orcid":false,"given":"Huili","family":"Zheng","sequence":"additional","affiliation":[{"name":"National Registry of Diseases Office, Health Promotion Board Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8728-0188","authenticated-orcid":false,"given":"Zi Hui Celeste","family":"Ng","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-4105","authenticated-orcid":false,"given":"Pin Pin","family":"Pek","sequence":"additional","affiliation":[{"name":"Pre\u2010Hospital and Emergency Research Centre, Health Services &amp; 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Systems Research, Duke NUS Medical School Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6043-0713","authenticated-orcid":false,"given":"Jasper","family":"Tromp","sequence":"additional","affiliation":[{"name":"Saw Swee Hock School of Public Health National University of Singapore &amp; the National University Health System Singapore"},{"name":"Duke\u2010NUS Medical School Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7874-7612","authenticated-orcid":false,"given":"Marcus Eng Hock","family":"Ong","sequence":"additional","affiliation":[{"name":"Pre\u2010Hospital and Emergency Research Centre, Health Services &amp; Systems Research, Duke\u2010NUS Medical School Singapore"},{"name":"Department of Emergency Medicine Singapore General Hospital Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9657-2411","authenticated-orcid":false,"given":"Jun Wei","family":"Yeo","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalini","family":"Arulanandam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2021.12.026"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2019.11.024"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2022.04.027"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.116.304521"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2018.11.002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2020.10.048"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2021.0127"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2022.100672"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2019.02.039"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.13546"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0310057x1504300504"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2011.01132.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015368"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2021114"},{"key":"e_1_3_2_16_2","unstructured":"Singapore Myocardial Infarction Registry annual report 2020. 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