{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:19:33Z","timestamp":1780755573702,"version":"3.54.1"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,12,19]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Catheter ablation of premature ventricular contractions (PVCs) that trigger polymorphic ventricular tachycardia (PVT) or ventricular fibrillation has been reported as a novel therapy to reduce the syncope events in patients with catecholaminergic PVT, whereas the long\u2010term ablation outcome and its value in improving exercise\u2010induced ventricular arrhythmias remain unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Fourteen consecutive selected patients with catecholaminergic PVT (mean\u00b1SD age, 16\u00b16\u2009years; 43% male patients) treated with maximum \u03b2\u2010blockers with no possibility of adding flecainide were prospectively enrolled for catheter ablation. The primary end point was syncope recurrence, and the secondary end point was the reduction of the ventricular arrhythmia score during exercise testing. Twenty\u2010six PVT\/ventricular fibrillation\u2013triggering PVCs were identified for ablation. The trigger beats arose from the left ventricle in 50% of the cases and from both ventricles in 36% of the cases. Purkinje potentials were observed at 27% of the targets. After a mean follow\u2010up of 49\u2009months after ablation, 8 (57%) patients were free from syncope recurrence. Ablation of trigger beat significantly reduced the syncope frequency (mean\u00b1SD, 4.3\u00b11.6 to 0.5\u00b10.8 events per year;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and improved the ventricular arrhythmia scores at the 3\u2010month (5 [range, 3\u20136] to 1.5 [range, 0\u20135];\n              <jats:italic>P<\/jats:italic>\n              =0.002) and 12\u2010month (5 [range, 3\u20136] to 2 [range, 0\u20135];\n              <jats:italic>P<\/jats:italic>\n              =0.014) follow\u2010ups. The induction of nontriggering PVCs postablation was closely associated with syncope recurrence (hazard ratio, 6.8 [95% CI, 1.3\u201335.5];\n              <jats:italic>P<\/jats:italic>\n              =0.026).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Catheter ablation of PVT\/ventricular fibrillation\u2013triggering PVCs in patients with catecholaminergic PVT who cannot receive flecainide treatment seems to be a safe and feasible adjunctive treatment that may reduce the syncope burden and improve exercise\u2010related ventricular arrhythmias. Induction of nontriggering PVCs after ablation is associated with a higher risk of syncope recurrence.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.031768","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T11:06:49Z","timestamp":1702033609000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Electrophysiological Characteristics and Ablation Outcomes in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia"],"prefix":"10.1161","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-4215","authenticated-orcid":false,"given":"Lishui","family":"Shen","sequence":"first","affiliation":[{"name":"Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Department of Cardiology, Shanghai Tenth People\u2019s Hospital Tongji University 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