{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:07Z","timestamp":1787018107929,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,2,6]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The Society for Cardiovascular Angiography and Interventions proposed a staging system (A\u2013E) to predict prognosis in cardiogenic shock. Herein, we report clinical outcomes of the RECOVER III study for the first time, according to Society for Cardiovascular Angiography and Interventions shock classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The RECOVER III study is an observational, prospective, multicenter, single\u2010arm, postapproval study of patients with acute myocardial infarction with cardiogenic shock undergoing percutaneous coronary intervention with Impella support. Patients enrolled in the RECOVER III study were assigned a baseline Society for Cardiovascular Angiography and Interventions shock stage. Staging was then repeated within 24\u2009hours after initiation of Impella. Kaplan\u2010Meier survival curve analyses were conducted to assess survival across Society for Cardiovascular Angiography and Interventions shock stages at both time points. At baseline assessment, 16.5%, 11.4%, and 72.2% were classified as stage C, D, and E, respectively. At \u226424\u2010hour assessment, 26.4%, 33.2%, and 40.0% were classified as stage C, D, and E, respectively. Thirty\u2010day survival among patients with stage C, D, and E shock at baseline was 59.7%, 56.5%, and 42.9%, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      =0.003). Survival among patients with stage C, D, and E shock at \u226424\u2009hours was 65.7%, 52.1%, and 29.5%, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). After multivariable analysis of impact of shock stage classifications at baseline and\u2009\u226424\u2009hours, only stage E classification at \u226424\u2009hours was a significant predictor of mortality (odds ratio, 4.8;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In a real\u2010world cohort of patients with acute myocardial infarction with cardiogenic shock undergoing percutaneous coronary intervention with Impella support, only stage E classification at \u226424\u2009hours was significantly predictive of mortality, suggesting that response to therapy may be more important than clinical severity of shock at presentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.031803","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T06:19:11Z","timestamp":1706681951000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Treatment of Acute Myocardial Infarction and Cardiogenic Shock: Outcomes of the RECOVER III Postapproval Study by Society of Cardiovascular Angiography and Interventions Shock Stage"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0481-9764","authenticated-orcid":false,"given":"Ivan D.","family":"Hanson","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine William Beaumont University Hospital Royal Oak MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-448X","authenticated-orcid":false,"given":"Akash","family":"Rusia","sequence":"additional","affiliation":[{"name":"Department of Advanced Heart Failure, Baylor Scott &amp; White Health\u2013The Heart Hospital Plano TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Palomo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine William Beaumont University Hospital Royal Oak MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7803-3126","authenticated-orcid":false,"given":"Adam","family":"Tawney","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine William Beaumont University Hospital Royal Oak MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Pow","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine William Beaumont University Hospital Royal Oak MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-2451","authenticated-orcid":false,"given":"Simon R.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine William Beaumont University Hospital Royal Oak MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6350-4666","authenticated-orcid":false,"given":"Perwaiz","family":"Meraj","sequence":"additional","affiliation":[{"name":"Department of Cardiology Northwell Health Manhasset NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Sievers","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Jackson\u2010Madison County Hospital Jackson TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4096-7916","authenticated-orcid":false,"given":"Michael","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Cardiology Piedmont Augusta Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6606-2261","authenticated-orcid":false,"given":"David","family":"Wohns","sequence":"additional","affiliation":[{"name":"Division of Cardiology Spectrum Health Grand Rapids MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0038-6058","authenticated-orcid":false,"given":"Omar","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Cardiology Detroit Medical Center Detroit MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin K.","family":"Kapur","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tufts University School of Medicine Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1653-6443","authenticated-orcid":false,"given":"Cindy","family":"Grines","sequence":"additional","affiliation":[{"name":"Northside Hospital Cardiovascular Institute Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-2466","authenticated-orcid":false,"given":"Daniel","family":"Burkhoff","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Hackensack University Medical Center Hackensack NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Lansky","sequence":"additional","affiliation":[{"name":"Yale New Haven Hospital New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srihari S.","family":"Naidu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Westchester Medical Center and New York Medical College Valhalla NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3486-6753","authenticated-orcid":false,"given":"Mir B.","family":"Basir","sequence":"additional","affiliation":[{"name":"Division of Cardiology Henry Ford Hospital Detroit MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5896-728X","authenticated-orcid":false,"given":"William","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Division of Cardiology Henry Ford Hospital Detroit MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000525"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908263410901"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1710261"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscai.2023.100586"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208410"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.05.065"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28307"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.01.018"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2017.09.007"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.04.049"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.1643"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28707"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29319"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30484"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29139"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.07.077"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004948"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2018.03.024"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2263"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2022.04.004"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.031803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:21:10Z","timestamp":1715588470000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.031803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,6]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2,6]]}},"alternative-id":["10.1161\/JAHA.123.031803"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.031803","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,6]]},"assertion":[{"value":"2023-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e031803"}}