{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:13:00Z","timestamp":1785366780194,"version":"3.55.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,20]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Electrocardiographic abnormalities are common in arrhythmogenic right ventricular cardiomyopathy and are included in the 2010 Task Force Criteria. Their time course, however, remains uncertain. In this retrospective observational study, we aimed to assess the long\u2010term evolution of electrocardiographic characteristics and their relation to ventricular arrhythmias.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Three hundred fifty\u2010three patients with arrhythmogenic right ventricular cardiomyopathy as per the 2010 Task Force Criteria with 6871 automatically processed 12\u2010lead digital ECGs were included. The relationship between the electrocardiographic parameters and the risk of ventricular arrhythmias was assessed at 10\u2009years from the first ECG. Electrocardiographic parameters were compared between the first contact ECG, the ECG at diagnosis, and the most recent ECG. Median time between the first and the latest ECG was 6 [interquartile range, 1\u201314] years. Reductions of QRS voltage, R\u2010 and T\u2010wave amplitudes between the first, diagnostic, and the latest ECGs were observed across precordial and extremity leads. Mean QRS duration increased from 96 to 102\u2009ms (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), terminal activation duration (V\n              <jats:sub>1<\/jats:sub>\n              ) from 47 to 52\u2009ms (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and QTc from 419 to 432 ms (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). T\u2010wave inversions in leads V\n              <jats:sub>3<\/jats:sub>\n              to V\n              <jats:sub>6<\/jats:sub>\n              and aVF at first ECG were associated with ventricular arrhythmias (adjusted hazard ratio [HR\n              <jats:sub>adj<\/jats:sub>\n              ][V\n              <jats:sub>3<\/jats:sub>\n              ], 2.03 [95% CI, 1.23\u20133.34] and HR\n              <jats:sub>adj<\/jats:sub>\n              [aVF], 1.87 [95% CI, 1.13\u20133.08]).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Depolarization and repolarization parameters evolved over time in patients with arrhythmogenic right ventricular cardiomyopathy, supporting the progressive nature of arrhythmogenic right ventricular cardiomyopathy. Electrocardiographic abnormalities may be detected before diagnosis and might, although not fulfilling the 2010 Task Force Criteria, be markers of early disease. T\u2010wave inversion in leads V\n              <jats:sub>3<\/jats:sub>\n              or aVF before diagnosis was associated with ventricular arrhythmias during follow\u2010up.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.031893","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T14:42:31Z","timestamp":1724078551000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Natural Course of Electrocardiographic Features in Arrhythmogenic Right Ventricular Cardiomyopathy and Their Relation to Ventricular Arrhythmic Events"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8404-0541","authenticated-orcid":false,"given":"Anneli","family":"Svensson","sequence":"first","affiliation":[{"name":"Department of Cardiology Link\u00f6ping University Hospital Link\u00f6ping Sweden"},{"name":"Department of Health, Medicine and Caring Sciences Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1802-4302","authenticated-orcid":false,"given":"Henrik Kjaerulf","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7550-0489","authenticated-orcid":false,"given":"Machteld J.","family":"Boonstra","sequence":"additional","affiliation":[{"name":"Division of Heart and Lungs, Department of Cardiology University Medical Center Utrecht, Utrecht University, Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD\u2010Heart\u2019 (ERN GUARDHEART; Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"T\u00e9treault\u2010Langlois","sequence":"additional","affiliation":[{"name":"Department of Medicine Montreal Heart Institute, University of Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3344-1796","authenticated-orcid":false,"given":"Pia","family":"Dahlberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Department of Molecular and Clinical Medicine Institute of Medicine, Sahlgrenska Academy Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-7049","authenticated-orcid":false,"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[{"name":"Unit for Inherited Cardiac Diseases, the Heart Center The National University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex H\u00f8rby","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital Herlev\u2010Gentofte Herlev Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Science University of Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5921-3786","authenticated-orcid":false,"given":"Rebecca T.","family":"Rylance","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-8515","authenticated-orcid":false,"given":"Jesper H.","family":"Svendsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Science University of Copenhagen Denmark"},{"name":"Department of Cardiology, the Heart Centre Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7489-8744","authenticated-orcid":false,"given":"Julia","family":"Cadrin\u2010Tourigny","sequence":"additional","affiliation":[{"name":"Department of Medicine Montreal Heart Institute, University of Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4694-4790","authenticated-orcid":false,"given":"Anneline S. J. M.","family":"te Riele","sequence":"additional","affiliation":[{"name":"Division of Heart and Lungs, Department of Cardiology University Medical Center Utrecht, Utrecht University, Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD\u2010Heart\u2019 (ERN GUARDHEART; Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5592-8717","authenticated-orcid":false,"given":"Pyotr G.","family":"Platonov","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Sciences Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq025"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.01.017"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.05.065"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-15-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.05.095"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz669"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1701400"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa084"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.01.031"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz103"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.120.008509"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/14017431.2015.1086017"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-019-1270-1"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.08.031"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa039"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-017-0696-x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14295"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw631"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12285"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000354"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.182949"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12080"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.01.065"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.114.001003"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.05.017"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01140.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.07.012"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-017-0572-8"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2014.07.022"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz570"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X16666200810105029"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.120.008121"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.031893","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T09:29:45Z","timestamp":1732786185000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.031893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,20]]},"references-count":33,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2024,8,20]]}},"alternative-id":["10.1161\/JAHA.123.031893"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.031893","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,20]]},"assertion":[{"value":"2023-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e031893"}}