{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:19:19Z","timestamp":1790774359135,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,4,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Peripheral artery disease is characterized by an intense inflammatory process that can be associated with a higher mortality rate, particularly in chronic limb\u2010threatening ischemia (CLTI). This study aims to compare the evolution of inflammatory markers between patients with claudication with those with CLTI at 3, 6, and 12\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      An observational, single\u2010center, and prospective study was conducted. A total of 119 patients with peripheral artery disease (65 with claudication and 54 with CLTI) were observed and inflammatory markers collected at admission and 3, 6, and 12\u2009months. At admission, patients with CLTI, when compared with patients with claudication, had significantly higher serum levels of C\u2010reactive protein and fibrinogen (positive acute\u2010phase proteins) and lower serum level of albumin, total cholesterol, and high\u2010density lipoprotein (negative acute\u2010phase proteins): C\u2010reactive protein (g\/dL), 2.90 (25th\u201375th percentile, 2.90\u20134.90) versus 6.80 (25th\u201375th percentile, 2.90\u201353.26) (\n                      <jats:italic>P<\/jats:italic>\n                      =0.000); fibrinogen (mg\/dL), 293.00 (25th\u201375th percentile, 269.25\u2013349.00) versus 415.50 (25th\u201375th percentile, 312.00\u2013615.75) (\n                      <jats:italic>P<\/jats:italic>\n                      =0.000); total cholesterol (mg\/dL), 161.79\u00b195% [152.74\u2013170.85] versus 146.42%\u00b195% [135.30\u2013157.53] (\n                      <jats:italic>P<\/jats:italic>\n                      =0.034); high\u2010density lipoprotein (mg\/dL), 50.00 (25th\u201375th percentile, 41.00\u201360.00) versus 37.00 (25th\u201375th percentile, 30.00\u201345.50) (\n                      <jats:italic>P<\/jats:italic>\n                      =0.000); albumin (g\/dL): 4.00 (25th\u201375th percentile, 3.70\u20134.20) versus 3.60 (25th\u201375th percentile, 3.10\u20134.00) (\n                      <jats:italic>P<\/jats:italic>\n                      =0.003). The association between CLTI and total cholesterol was lost after adjusting for confounders. Three months after the resolution of the CLTI, there was an increase in the levels of negative acute\u2010phase proteins and a decrease in positive acute\u2010phase proteins. These inflammatory proteins did not register an evolution in patients with claudication. The differences in the inflammatory proteins between groups disappeared at 6\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">CLTI has an inflammatory environment that can be partially reverted after resolution of the ischemic process, emphasizing the importance of timely intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.031922","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T07:12:09Z","timestamp":1712905929000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Reversion of the Inflammatory Markers in Patients With Chronic Limb\u2010Threatening Ischemia"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6761-4881","authenticated-orcid":false,"given":"Joana","family":"Ferreira","sequence":"first","affiliation":[{"name":"Vascular Surgery Department\u2014Physiology and Surgery Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o Porto Portugal"},{"name":"Life and Health Science Research Institute (ICVS), School of Medicine University of Minho Braga Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associated Laboratory Braga Portugal"},{"name":"Academic Center Hospital da Senhora da Oliveira Guimar\u00e3es Portugal"},{"name":"Clinical Academic Center Hospital de Tr\u00e1s\u2010os\u2010Montes e Alto Douro\u2014Professor Doutor Nuno Grande\u2014CACTMAD Vila Real 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Associated Laboratory Braga Portugal"},{"name":"Department of Pathology (LIM\u201014) University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"},{"name":"Molecular Oncology Research Center Barretos Cancer Hospital Barretos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7777-5865","authenticated-orcid":false,"suffix":"Nurse","given":"Isabel","family":"Vila","sequence":"additional","affiliation":[{"name":"Academic Center Hospital da Senhora da Oliveira Guimar\u00e3es Portugal"},{"name":"Center for the Research and Treatment of Arterial Hypertension and Cardiovascular Risk, Hospital da Senhora da Oliveira Guimar\u00e3es Portugal"},{"name":"Internal Medicine Department Hospital da Senhora da Oliveira, Guimar\u00e3es Braga 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