{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:48:25Z","timestamp":1793090905588,"version":"4.5.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,2,20]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Although accumulating data indicate that IL\u20106 (interleukin\u20106) can promote heart rate\u2010corrected QT interval (QTc) prolongation via direct and indirect effects on cardiac electrophysiology, current evidence comes from basic investigations and small clinical studies only. Therefore, IL\u20106 is still largely ignored in the clinical management of long\u2010QT syndrome and related arrhythmias. The aim of this study was to estimate the risk of QTc prolongation associated with elevated IL\u20106 levels in a large population of unselected subjects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">An observational study using the Veterans Affairs Informatics and Computing Infrastructure was performed. Participants were US veterans who had an ECG and were tested for IL\u20106. Descriptive statistics and univariate and multivariate regression analyses were performed to study the relationship between IL\u20106 and QTc prolongation risk. Study population comprised 1085 individuals, 306 showing normal (&lt;5\u2009pg\/mL), 376 moderately high (5\u201325\u2009pg\/mL), and 403 high (&gt;25\u2009pg\/mL) IL\u20106 levels. Subjects with elevated IL\u20106 showed a concentration\u2010dependent increase in the prevalence of QTc prolongation, and those presenting with QTc prolongation exhibited higher circulating IL\u20106 levels. Stepwise multivariate regression analyses demonstrated that increased IL\u20106 level was significantly associated with a risk of QTc prolongation up to 2 times the odds of the reference category of QTc (e.g. QTc &gt;470 ms men\/480 ms women ms: odds ratio, 2.28 [95% CI, 1.12\u20134.50] for IL\u20106 &gt;25 pg\/mL) regardless of the underlying cause. Specifically, the mean QTc increase observed in the presence of elevated IL\u20106 was quantitatively comparable (IL\u20106 &gt;25\u2009pg\/mL:+6.7 ms) to that of major recognized QT\u2010prolonging risk factors, such as hypokalemia and history of myocardial infarction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Our data provide evidence that a high circulating IL\u20106 level is a robust risk factor for QTc prolongation in a large cohort of US veterans, supporting a potentially important arrhythmogenic role for this cytokine in the general population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032071","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T10:39:35Z","timestamp":1707820775000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Elevated Interleukin\u20106 Levels Are Associated With an Increased Risk of QTc Interval Prolongation in a Large Cohort of US Veterans"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6721-1214","authenticated-orcid":false,"given":"Pietro Enea","family":"Lazzerini","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Surgery and Neurosciences University of Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Cupelli","sequence":"additional","affiliation":[{"name":"VA New York Harbor Healthcare System New York NY USA"},{"name":"SUNY Downstate Health Sciences University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-6275","authenticated-orcid":false,"given":"Alessandra","family":"Cartocci","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies University of Siena Siena 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