{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T08:05:23Z","timestamp":1783670723605,"version":"3.55.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Adverse left ventricular remodeling is a significant cardiovascular predictor for patients with coronary artery disease and preserved left ventricular ejection fraction (LVEF). However, the remodeling indexes reflecting left ventricular spherization by myocardial perfusion imaging are underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      727 patients (mean age 59.8\u00b113.5\u2009years, 329 women) diagnosed or suspected coronary artery disease with preserved LVEF who underwent resting myocardial perfusion imaging were retrospectively enrolled. The myocardial perfusion imaging findings including the total perfusion deficit and sphericity indexes (shape index (SI) and eccentricity index (EI) obtained from gated (QGS) and non\u2010gated (QPS) images) were collected. Major adverse cardiovascular events (MACE) were followed up for 45.1\u00b122.0\u2009months. All patients were divided into 4 subgroups based on total perfusion deficit at 10% and LVEF at 65%. Univariable comparative analyses were performed in 5 cohorts (all patients and 4 subgroups). Patients who experienced MACE displayed higher SI and\/or lower EI (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.05). Kaplan\u2013Meier survival analyses suggested significant differences for SI\n                      <jats:sub>QPS<\/jats:sub>\n                      in all 5 cohorts, for EI\n                      <jats:sub>QPS<\/jats:sub>\n                      and EI\n                      <jats:sub>QGS<\/jats:sub>\n                      in 4 cohorts, and for end\u2010systolic and end\u2010diastolic SI\n                      <jats:sub>QGS<\/jats:sub>\n                      in 3 cohorts (all\u00a0\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.05). Multivariate Cox analysis showed that abnormal SI and EI remained statistically significant predictors for MACE after adjusting for total perfusion deficit, LVEF, and other confounding factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      For patients diagnosed or suspected of coronary artery disease with preserved or supra\u2010normal LVEF, resting sphericity indexes by myocardial perfusion imaging displayed incremental long\u2010term prognostic value. Among these indicators, SI\n                      <jats:sub>QPS<\/jats:sub>\n                      is particularly promising across different perfusion or preserved functional conditions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.032169","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T07:05:34Z","timestamp":1724742334000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic Value of Resting Left Ventricular Sphericity Indexes in Coronary Artery Disease With Preserved Ejection Fraction"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2397-2761","authenticated-orcid":false,"given":"Ping","family":"Wu","sequence":"first","affiliation":[{"name":"First Hospital of Shanxi Medical University","place":["Taiyuan, China"]},{"name":"Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Zhao","sequence":"additional","affiliation":[{"name":"First Hospital of Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6671-7053","authenticated-orcid":false,"given":"Xiaoshan","family":"Guo","sequence":"additional","affiliation":[{"name":"First Hospital of Shanxi Medical University","place":["Taiyuan, China"]},{"name":"Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Hu","sequence":"additional","affiliation":[{"name":"First Hospital of Shanxi Medical University","place":["Taiyuan, China"]},{"name":"Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Xiao","sequence":"additional","affiliation":[{"name":"First Hospital of Shanxi Medical University","place":["Taiyuan, China"]},{"name":"Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3242-5516","authenticated-orcid":false,"given":"Li","family":"Xu","sequence":"additional","affiliation":[{"name":"First Hospital of Shanxi Medical University","place":["Taiyuan, China"]},{"name":"Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Huang","sequence":"additional","affiliation":[{"name":"First Hospital of Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"First Hospital of Shanxi Medical University","place":["Taiyuan, China"]},{"name":"Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4342-6779","authenticated-orcid":false,"given":"Yanhui","family":"Wang","sequence":"additional","affiliation":[{"name":"First Hospital of Shanxi Medical University","place":["Taiyuan, China"]},{"name":"Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1488-4745","authenticated-orcid":false,"given":"Tailin","family":"Ren","sequence":"additional","affiliation":[{"name":"First Hospital of Shanxi Medical University","place":["Taiyuan, China"]},{"name":"Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8804-6782","authenticated-orcid":false,"given":"Qiuyan","family":"Wu","sequence":"additional","affiliation":[{"name":"First Hospital of Shanxi Medical University","place":["Taiyuan, China"]},{"name":"Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1240-4745","authenticated-orcid":false,"given":"Ruonan","family":"Wang","sequence":"additional","affiliation":[{"name":"First Hospital of Shanxi Medical University","place":["Taiyuan, China"]},{"name":"Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Anzhen Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifang","family":"Wu","sequence":"additional","affiliation":[{"name":"First Hospital of Shanxi Medical University","place":["Taiyuan, China"]},{"name":"Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2010-3459","authenticated-orcid":false,"given":"Sijin","family":"Li","sequence":"additional","affiliation":[{"name":"First Hospital of Shanxi Medical University","place":["Taiyuan, China"]},{"name":"Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-019-09831-z"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.11.022"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0253-3758.2017.08.018"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-018-1283-y"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2014.02.025"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-008-9018-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-011-9449-x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-010-9297-0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nuclcard.2004.10.006"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-019-01465-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-017-1090-x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.260141"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-021-05566-y"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-020-04892-x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz550"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13101756"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-018-01518-0"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.02.028"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nuclcard.2006.05.020"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.15420\/ecr.2015:9:3"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.25.2981"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-017-0777-3"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.07.022"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00630-0"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12780"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-310052"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.01.003"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.09.028"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.15420\/ecr.2019.5.1"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.5812\/cardiovascmed.29005"},{"key":"e_1_3_2_32_2","first-page":"2138","article-title":"Automatic quantification of ejection fraction from gated myocardial perfusion SPECT","volume":"36","author":"Germano G","year":"1995","unstructured":"Germano G, Kiat H, Kavanagh PB, Moriel M, Mazzanti M, Su HT, Van Train KF, Berman DS. Automatic quantification of ejection fraction from gated myocardial perfusion SPECT. J Nucl Med. 1995;36:2138\u20132147.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_33_2","first-page":"805","article-title":"201Tl and 99mTc\u2010MIBI gated SPECT in patients with large perfusion defects and left ventricular dysfunction: comparison with equilibrium radionuclide angiography","volume":"40","author":"Manrique A","year":"1999","unstructured":"Manrique A, Faraggi M, V\u00e9ra P, Vilain D, Lebtahi R, Cribier A, Le Guludec D. 201Tl and 99mTc\u2010MIBI gated SPECT in patients with large perfusion defects and left ventricular dysfunction: comparison with equilibrium radionuclide angiography. J Nucl Med. 1999;40:805\u2013809.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-3581(98)90197-0"},{"key":"e_1_3_2_35_2","first-page":"874","article-title":"Reproducibility and accuracy of gated SPECT for determination of left ventricular volumes and ejection fraction: experimental validation using MRI","volume":"41","author":"Vallejo E","year":"2000","unstructured":"Vallejo E, Dione DP, Bruni WL, Constable RT, Borek PP, Soares JP, Carr JG, Condos SG, Wackers FJ, Sinusas AJ. Reproducibility and accuracy of gated SPECT for determination of left ventricular volumes and ejection fraction: experimental validation using MRI. J Nucl Med. 2000;41:874\u2013882.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_36_2","first-page":"436A","article-title":"Improved accuracy of SPECT LVEF using numerical modeling of ventricular image blurring for patients with small hearts","volume":"33","author":"Case JA","year":"1999","unstructured":"Case JA, Bateman TM, Cullom SJ, O'Keefe JH, Moutray KL, Saunders MJ. Improved accuracy of SPECT LVEF using numerical modeling of ventricular image blurring for patients with small hearts. J Am Coll Cardiol. 1999;33:436A.","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.032169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:03:03Z","timestamp":1769691783000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.032169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,3]]},"references-count":35,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2024,9,3]]}},"alternative-id":["10.1161\/JAHA.123.032169"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.032169","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,3]]},"assertion":[{"value":"2023-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e032169"}}