{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:06Z","timestamp":1787018106438,"version":"build-2736575974"},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,5,7]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Guidelines for the use of antihypertensives changed in 2014 and 2017. To understand the effect of these guidelines, we examined trends in antihypertensive prescriptions in the United States from 2010 to 2019 using a repeated cross\u2010sectional design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Using electronic health records from 15 health care institutions for adults (20\u201385\u2009years old) who had \u22651 antihypertensive prescription, we assessed whether (1) prescriptions of beta blockers decreased after the 2014 Eighth Joint National Committee (JNC 8) report discouraged use for first\u2010line treatment, (2) prescriptions for calcium channel blockers and thiazide diuretics increased among Black patients after the JNC 8 report encouraged use as first\u2010line therapy, and (3) prescriptions for dual therapy and fixed\u2010dose combination among patients with blood pressure \u2265140\/90\u2009mm\u2009Hg increased after recommendations in the 2017\u00a0Hypertension Clinical Practice Guidelines. The study included 1\u2009074\u2009314 patients with 2\u2009133\u2009158 prescription episodes. After publication of the JNC 8 report, prescriptions for beta blockers decreased (3% lower in 2018\u20132019 compared to 2010\u20132014), and calcium channel blockers increased among Black patients (20% higher in 2015\u20132017 and 41% higher in 2018\u20132019, compared to 2010\u20132014), in accordance with guideline recommendations. However, contrary to guidelines, dual therapy and fixed\u2010dose combination decreased after publication of the 2017 Hypertension Clinical Practice Guidelines\u00a0(9% and 11% decrease in 2018\u20132019 for dual therapy and fixed\u2010dose combination, respectively, compared to 2015\u20132017), and thiazide diuretics decreased among Black patients after the JNC\u00a08 report (6% lower in 2018\u20132019 compared to 2010\u20132014).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Adherence to guidelines on prescribing antihypertensive medication was inconsistent, presenting an opportunity for interventions to achieve better blood pressure control in the US population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.032197","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T07:08:42Z","timestamp":1713510522000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Trends of Antihypertensive Prescription Among US Adults From 2010 to 2019 and Changes Following Treatment Guidelines: Analysis of Multicenter Electronic Health Records"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3564-4255","authenticated-orcid":false,"given":"Pi\u2010I Debby","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl","family":"Rifas\u2010Shiman","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Merriman","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Petimar","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Boston MA USA"},{"name":"Department of Epidemiology Harvard TH Chan School of Public Health Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1309-4096","authenticated-orcid":false,"given":"Matthew F.","family":"Daley","sequence":"additional","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8493-610X","authenticated-orcid":false,"given":"David M.","family":"Janicke","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9706-6860","authenticated-orcid":false,"given":"William J.","family":"Heerman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8967-0662","authenticated-orcid":false,"given":"L. Charles","family":"Bailey","sequence":"additional","affiliation":[{"name":"Applied Clinical Research Center, Children\u2019s Hospital of Philadelphia Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3212-1651","authenticated-orcid":false,"given":"Carlos","family":"Maeztu","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Biomedical Informatics University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2758-6932","authenticated-orcid":false,"given":"Jessica","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Boston MA USA"},{"name":"Department of Epidemiology Harvard TH Chan School of Public Health Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7660-9064","authenticated-orcid":false,"given":"Jason P.","family":"Block","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008888"},{"key":"e_1_3_2_3_2","unstructured":"Centers for Disease Control and Prevention . Hypertension cascade: hypertension prevalence treatment and control estimates among U.S. Adults Aged 18\u2009Years and Older Applying the Criteria from the American College of Cardiology and American Heart Association's 2017 Hypertension Guideline\u2014NHANES 2017\u20132020. Centers for Disease Control and Prevention (CDC). Accessed May 12 2023. https:\/\/millionhearts.hhs.gov\/data\u2010reports\/hypertension\u2010prevalence.html"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.15620\/cdc:133059"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31679-8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-022-07612-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19222"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16418"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40885-016-0042-0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.026652"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2010.00397.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000066"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.04.032"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1010539520965280"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpab137"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/ANS.0000000000000263"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2007.06112.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.5334\/egems.199"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2016.10.016"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2014-002747"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2020.09.036"},{"key":"e_1_3_2_23_2","unstructured":"National Library of Medicine . Unified Medical Language System RxNorm. Updated 5 October 2022. Accessed February 27 2024. https:\/\/www.nlm.nih.gov\/research\/umls\/rxnorm\/index.html"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.153249"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/jamiaopen\/ooac089"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocx037"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/73.1.13"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.25127"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14360"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.14545"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.116.003166"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000659"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.08.019"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.06.001"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.118.005624"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022224"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.704023"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000791512.37549.64"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000118019.28487.9c"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17102"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2022.01.210276"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.119.006115"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-020-0340-6"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hci139"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000254479.66645.a3"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806182"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159366"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2022.100219"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13426"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12308"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.6.2.275"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.542290"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.096156"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000229653.73128.b6"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16050721"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.130"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.5334\/egems.274"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.0790"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2014-002743"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocab221"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2014-002745"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/22.172"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.123.032197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:13:15Z","timestamp":1715587995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.123.032197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,7]]},"references-count":63,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,5,7]]}},"alternative-id":["10.1161\/JAHA.123.032197"],"URL":"https:\/\/doi.org\/10.1161\/jaha.123.032197","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,7]]},"assertion":[{"value":"2023-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e032197"}}