{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T18:40:55Z","timestamp":1777315255252,"version":"3.51.4"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Aging of the proximal aorta can lead to increased pressure and flow pulsatility in the cerebral microcirculation, which may cause cognitive impairment. This study investigated the association between aortic characteristic impedance (Zc), an indicator of regional stiffness of the proximal aorta, and suspected mild cognitive impairment (MCI), compared with carotid\u2013femoral pulse wave velocity (CFPWV).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">A total of 1461 healthy community residents (46.4% men; age range, 35\u201396\u2009years [mean\u00b1SD, 59.9\u00b111.8\u2009years]) without a history of cardiovascular events or stroke were included in the study. Zc was estimated using applanation tonometry and echocardiography. Cognitive function was assessed using the Mini\u2010Mental State Examination. Education\u2010adjusted cut points were used to define suspected MCI. Subjects with suspected MCI (n=493 [33.7%]) had significantly higher Zc and CFPWV than those without. In multivariable analysis, both Zc and CFPWV were inversely associated with Mini\u2010Mental State Examination score. Zc (odds ratio per 1 SD, 1.22 [95% CI, 1.09\u20131.37] and CFPWV (odds ratio per 1 SD, 1.18 [95% CI, 1.01\u20131.38]) was also significantly associated with suspected MCI, after adjusting for age, sex, education level, mean arterial pressure, hypertension, diabetes, low\u2010density lipoprotein cholesterol, and smoking status. In joint analysis, Zc was significantly associated with suspected MCI, but CFPWV was not. In the age subgroups of &lt;50\u2009years and 50 to 70\u2009years, only Zc was significantly associated with suspected MCI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">This study found that Zc was significantly associated with Mini\u2010Mental State Examination score and suspected MCI, especially in younger and middle\u2010aged adults. These findings suggest that Zc may be a useful biomarker for identifying individuals at risk for MCI.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032268","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T10:40:52Z","timestamp":1703846452000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Aortic Characteristic Impedance and Suspected Mild Cognitive Impairment in a Community\u2010Based Healthy Population"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9177-6528","authenticated-orcid":false,"given":"Chao\u2010Feng","family":"Liao","sequence":"first","affiliation":[{"name":"Institute of Public Health, National Yang Ming Chiao Tung University College of Medicine Taipei Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2138-4771","authenticated-orcid":false,"given":"Shao\u2010Yuan","family":"Chuang","sequence":"additional","affiliation":[{"name":"Institute of Population Health Science, National Health Research Institute Miaoli Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3885-6600","authenticated-orcid":false,"given":"Hao\u2010Min","family":"Cheng","sequence":"additional","affiliation":[{"name":"Program of Interdisciplinary Medicine National Yang Ming Chiao Tung University College of Medicine Taipei Taiwan, R.O.C."},{"name":"Division of Faculty Development, Department of Medical Education Taipei Veterans General Hospital Taipei Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Hua","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Public Health, National Yang Ming Chiao Tung University College of Medicine Taipei Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-0287","authenticated-orcid":false,"given":"Chen\u2010Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Public Health, National Yang Ming Chiao Tung University College of Medicine Taipei Taiwan, R.O.C."},{"name":"Department of Medicine National Yang Ming Chiao Tung University College of Medicine Taipei Taiwan, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","first-page":"A34","article-title":"Dementia and its implications for public health","volume":"3","author":"Chapman DP","year":"2006","unstructured":"Chapman DP, Williams SM, Strine TW, Anda RF, Moore MJ. 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