{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:10:57Z","timestamp":1791587457657,"version":"4.3.4"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Hypertension is a significant risk factor for cardiovascular and chronic kidney diseases. Its management in young people remains limited. Device\u2010based therapies, such as low\u2010level tragus stimulation (LL\u2010TS), a noninvasive method that reduces sympathetic activity, have recently been explored for resistant hypertension.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This trial involved patients with Grade 1 hypertension with no other medical history. LL\u2010TS (20\u2009Hz, 1\u2009mA, 1\u2009h\/day) was applied for 3\u2009months on the tragus (Intervention group [IG]) or earlobe (Control group [CG]). Blood pressure and outcomes were assessed at the first, second, and third months. Among 40 patients, 21 were in IG and 19 in CG. Baseline systolic blood pressure was similar between IG (142.62\u00b18.18\u2009mm\u2009Hg) and CG (143.00\u00b18.61\u2009mm\u2009Hg),\n              <jats:italic>P<\/jats:italic>\n              =0.89. Post\u2010LL\u2010TS, systolic blood pressure showed significant reductions in IG compared with CG at the first (IG: 134.47\u00b15.95\u2009mm\u2009Hg, CG: 141.28\u00b16.78\u2009mm\u2009Hg,\n              <jats:italic>P<\/jats:italic>\n              =0.002), second (IG: 132.50\u00b17.51\u2009mm\u2009Hg, CG: 140.62\u00b17.15\u2009mm\u2009Hg,\n              <jats:italic>P<\/jats:italic>\n              =0.001), and third months (IG: 128.81\u00b17.13\u2009mm\u2009Hg, CG: 136.51\u00b17.96\u2009mm\u2009Hg,\n              <jats:italic>P<\/jats:italic>\n              =0.003). diastolic blood pressure also differed significantly: first month (IG: 85.34\u00b15.81\u2009mm\u2009Hg, CG: 89.74\u00b16.32\u2009mm\u2009Hg,\n              <jats:italic>P<\/jats:italic>\n              =0.03), second month (IG: 82.12\u00b15.22\u2009mm\u2009Hg, CG: 88.57\u00b17.11\u2009mm\u2009Hg,\n              <jats:italic>P<\/jats:italic>\n              =0.002), and third month (IG: 80.71\u00b15.96\u2009mm\u2009Hg, CG: 87.55\u00b15.26\u2009mm\u2009Hg,\n              <jats:italic>P<\/jats:italic>\n              =0.001). Heart rate was unchanged (\n              <jats:italic>P<\/jats:italic>\n              &gt;0.05). Only 0.01% of IG subjects reported site irritation, with no serious adverse events.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">LL\u2010TS led to significant blood pressure reductions in young patients with essential hypertension. Further larger trials are needed to confirm the safety and efficacy of LL\u2010TS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.chictr.org.cn\/\">https:\/\/www.chictr.org.cn\/<\/jats:ext-link>\n              ; Unique identifier: ChiCTR2000038448.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032269","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T09:31:23Z","timestamp":1726651883000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Low\u2010Level Tragus Stimulation Attenuates Blood Pressure in Young Individuals With Hypertension: Results From a Small\u2010Scale Single\u2010Blind Controlled Randomized Clinical Trial"],"prefix":"10.1161","volume":"13","author":[{"given":"Muisha B.","family":"Mbikyo","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Hospital of China Medical University Shenyang China"},{"name":"Department of Cardiology Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8477-5433","authenticated-orcid":false,"given":"Nan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxian","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2281-8332","authenticated-orcid":false,"given":"Zhao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Hospital of China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","first-page":"1","article-title":"Summary health statistics for U.S. adults: national health interview survey, 2012","volume":"10","author":"Blackwell DL","year":"2014","unstructured":"Blackwell DL, Lucas JW, Clarke TC. 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