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Obesity\u2010driven structural and electrical remodeling contribute to AF via several reported mechanisms, including adiposity, inflammation, fibrosis, oxidative stress, ion channel alterations, and autonomic dysfunction. In particular, expanding epicardial adipose tissue during obesity has been suggested as a key driver of AF via paracrine signaling and direct infiltration. Weight loss has been shown to reverse these changes and reduce AF risk and recurrence after ablation. However, studies on how obesity affects pharmacologic or interventional AF treatments are limited. In this review, we discuss mechanisms by which obesity mediates AF and treatment outcomes, aiming to provide insight into obesity\u2010drug interactions and guide personalized treatment for this patient subgroup.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.123.032277","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T05:13:30Z","timestamp":1703826810000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":142,"title":["Impact of Obesity on Atrial Fibrillation Pathogenesis and Treatment Options"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7729-5134","authenticated-orcid":false,"given":"Rina","family":"Sha","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Sciences, University of Birmingham Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8077-7559","authenticated-orcid":false,"given":"Olivia","family":"Baines","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, University of Birmingham Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbie","family":"Hayes","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, University of Birmingham Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4157-0387","authenticated-orcid":false,"given":"Katie","family":"Tompkins","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, University of Birmingham Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-5960","authenticated-orcid":false,"given":"Manish","family":"Kalla","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, University of Birmingham Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-9401","authenticated-orcid":false,"given":"Andrew P.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, University of Birmingham Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3030-7364","authenticated-orcid":false,"given":"Christopher","family":"O'Shea","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, University of Birmingham Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-3551","authenticated-orcid":false,"given":"Davor","family":"Pavlovic","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, University of Birmingham Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.595140"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009035"},{"key":"e_1_3_2_4_2","unstructured":"World Health Organization . 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