{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T02:38:07Z","timestamp":1769654287009,"version":"3.49.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,5,21]]},"abstract":"\n Background<\/jats:title>\n \n Genetic and familial contributions to early\u2010onset atrial fibrillation are described primarily in individuals of European ancestry. However, the role of racial and familial contributions in the pathogenesis of early\u2010onset atrial flutter (\n EOAFL<\/jats:styled-content>\n ) is unclear.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n In this cross\u2010sectional study, participants were enrolled prospectively from 2015 to 2021 in multiple academic centers with a diagnosis of atrial flutter (\n AFL)<\/jats:styled-content>\n confirmed by ECG.\n EOAFL<\/jats:styled-content>\n was defined as a diagnosis of\n AFL<\/jats:styled-content>\n before age 66\u2009years with no concomitant or previous diagnosis of atrial tachyarrhythmias. Family history was adjudicated through baseline questionnaires and direct family interviews about the diagnosis of atrial tachyarrhythmias, stroke, and cardiomyopathy. The primary exposure was a positive family history in first\u2010degree relatives, and the primary outcome was the odds of\n EOAFL<\/jats:styled-content>\n versus late\u2010onset\n AFL<\/jats:styled-content>\n . A total of 909 patients were enrolled. Participants with a positive family history of atrial tachyarrhythmias were younger, less likely to be of Black race, and more likely to have\n EOAFL<\/jats:styled-content>\n . The adjusted odds ratio (\n OR<\/jats:styled-content>\n ) for\n EOAFL<\/jats:styled-content>\n in those with a positive family history was 1.8 (95%\n CI<\/jats:styled-content>\n , 1.1\u20133.0). There was an increased odds of\n EOAFL<\/jats:styled-content>\n in those of Black race (\n OR,<\/jats:styled-content>\n 2.1 [95%\n CI,<\/jats:styled-content>\n 1.4\u20133.2]), alcohol use (\n OR,<\/jats:styled-content>\n 1.6 [95%\n CI,<\/jats:styled-content>\n 1.0\u20132.6]), and obstructive sleep apnea (\n OR,<\/jats:styled-content>\n 1.9 [95%\n CI,<\/jats:styled-content>\n 1.0\u20133.4]). Use of cardioselective \u03b2 blockers or calcium channel blockers before the diagnosis of\n AFL<\/jats:styled-content>\n were associated with a lower odds of\n EOAFL<\/jats:styled-content>\n (\n OR,<\/jats:styled-content>\n 0.5 [95%\n CI,<\/jats:styled-content>\n 0.2\u20130.9]).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These findings suggest a potentially hereditary predisposition to\n EOAFL<\/jats:styled-content>\n across race and ethnicity, warranting further study of the genetic contributions to\n AFL<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.123.032320","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T10:35:20Z","timestamp":1715337320000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Family History and Early\u2010Onset Atrial Flutter Across Racial and Ethnic 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Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3855-6891","authenticated-orcid":false,"given":"David S.","family":"Tofovic","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Illinois Chicago Chicago IL"},{"name":"College of Liberal Arts and Sciences, University of Illinois Chicago Chicago IL"},{"name":"Center for Cardiovascular Research University of Illinois Chicago Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4103-5977","authenticated-orcid":false,"given":"Dawood","family":"Darbar","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Illinois Chicago Chicago IL"},{"name":"College of Liberal Arts and Sciences, University of Illinois Chicago Chicago IL"},{"name":"Center for Cardiovascular Research University of Illinois Chicago Chicago 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