{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T01:43:45Z","timestamp":1794361425209,"version":"4.9.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,8,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">There is scant evidence regarding the safety of antiplatelet therapy in acute ischemic stroke (AIS) patients with thrombocytopenia. Our study aims to address this concern by examining AIS patients with thrombocytopenia from a large database in real\u2010world settings.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We included patients with AIS with a platelet count &lt;100\u00d710\n              <jats:sup>9<\/jats:sup>\n              \/L who had complete records of antiplatelet drug use. Those requiring anticoagulation or having contraindications to antiplatelet therapy were excluded. Short\u2010term safety outcomes were in\u2010hospital bleeding events, while the long\u2010term safety outcome was 1\u2010year all\u2010cause mortality. A good clinical outcome was defined as functional independence, indicated by a modified Rankin Scale score of 0 to 2 at discharge. Propensity score matched analyses were used. We screened 169\u2009423 patients with AIS from 90 stroke centers in the CASE II register, ultimately enrolling 2808 noncardioembolic patients with thrombocytopenia. In the propensity score matched analyses, no significant difference was observed between the antiplatelet and nonantiplatelet groups in terms of intracranial hemorrhage (odds ratio=0.855 [95% CI, 0.284\u20135.478];\n              <jats:italic>P<\/jats:italic>\n              =0.160) or gastrointestinal bleeding (odds ratio=2.034 [95% CI, 0.755\u20135.478];\n              <jats:italic>P<\/jats:italic>\n              =0.160). Antiplatelet therapy was associated with improved functional outcomes at discharge (odds ratio=1.405 [95% CI, 1.028\u20131.920];\n              <jats:italic>P<\/jats:italic>\n              =0.033), and showed a trend towards reducing 1\u2010year mortality (odds ratio=0.395 [95% CI, 0.152\u20131.031];\n              <jats:italic>P<\/jats:italic>\n              =0.058).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The use of antiplatelet therapy lessened as platelet count decreased in patients with AIS with thrombocytopenia. However, our findings suggest that antiplatelet medications remain safe and effective for this population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032327","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T11:34:42Z","timestamp":1723203282000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Safety of Antiplatelet Therapy in Noncardioembolic Ischemic Stroke With Thrombocytopenia: The CASE II Study"],"prefix":"10.1161","volume":"13","author":[{"given":"Dongjuan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurology Dongyang Affiliated Hospital of Wenzhou Medical University Dongyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Gong","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieming","family":"Zhong","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Center for Disease Control and Prevention Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology Yongjia people\u2019s Hospital Yongjia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology People\u2019s Hospital of Anji Anji China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wansi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6425-0672","authenticated-orcid":false,"given":"Shenqiang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6627-064X","authenticated-orcid":false,"given":"Min","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the CASE II 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