{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:09:57Z","timestamp":1781719797008,"version":"3.54.5"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,1,16]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Despite reducing cardiovascular disease (CVD) events and death in SPRINT (Systolic Blood Pressure Intervention Trial), intensive systolic blood pressure goals have not been adopted in the United States. This study aimed to simulate the potential long\u2010term impact of 4 hypertension management strategies in SPRINT\u2010eligible US adults.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">The validated Blood Pressure Control\u2013Cardiovascular Disease Policy Model, a discrete event simulation of hypertension care processes (ie, visit frequency, blood pressure [BP] measurement accuracy, medication intensification, and medication adherence) and CVD outcomes, was populated with 25\u2009000 SPRINT\u2010eligible US adults. Four hypertension management strategies were simulated: (1) usual care targeting BP &lt;140\/90\u2009mm\u2009Hg (Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure usual care), (2) intensive care per the SPRINT protocol targeting BP &lt;120\/90\u2009mm\u2009Hg (SPRINT intensive), (3) usual care targeting guideline\u2010recommended BP &lt;130\/80\u2009mm\u2009Hg (American College of Cardiology\/American Heart Association usual care), and (4) team\u2010based care added to usual care and targeting BP &lt;130\/80\u2009mm\u2009Hg. Relative to the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure usual care, among the 18.1\u2009million SPRINT\u2010eligible US adults, an estimated 138\u2009100 total CVD events could be prevented per year with SPRINT intensive, 33\u2009900 with American College of Cardiology\/American Heart Association usual care, and 89\u2009100 with team\u2010based care. Compared with the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure usual care, SPRINT intensive care was projected to increase treatment\u2010related serious adverse events by 77\u2009600 per year, American College of Cardiology\/American Heart Association usual care by 33\u2009300, and team\u2010based care by 27\u2009200.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">As BP control has declined in recent years, health systems must prioritize hypertension management and invest in effective strategies. Adding team\u2010based care to usual care may be a pragmatic way to manage risk in this high\u2010CVD\u2010risk population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032370","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T11:20:33Z","timestamp":1705058433000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of Hypertension Management Strategies in SPRINT\u2010Eligible US Adults: A\u00a0Simulation Study"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2380-0708","authenticated-orcid":false,"given":"Fengdi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Medicine Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7180-8064","authenticated-orcid":false,"given":"Kelsey 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Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2259-5039","authenticated-orcid":false,"given":"Adam P.","family":"Bress","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare Department of Population Health Sciences University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4461-8756","authenticated-orcid":false,"given":"James P.","family":"Sheppard","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6783-7951","authenticated-orcid":false,"given":"Jordan B.","family":"King","sequence":"additional","affiliation":[{"name":"Intermountain Healthcare Department of Population Health Sciences University of Utah Salt Lake City UT 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