{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T01:15:10Z","timestamp":1785201310839,"version":"3.55.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2024,2,20]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Information on the long\u2010term prognosis in patients with isolated thalamic stroke is sparse. We report the functional outcomes of patients with thalamic stroke up to 24\u2009months from the KOSCO (Korean Stroke Cohort for Functioning and Rehabilitation) study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Isolated thalamic stroke was defined as the presence of lesions solely in the thalamus, excluding cases with lesions in other brain parenchyma areas apart from the thalamus, as identified by brain magnetic resonance imaging or computed tomography scans. The Fugl\u2010Meyer Assessment, the Functional Ambulatory Category, the Korean Mini\u2010Mental State Examination, the American Speech\u2010Language\u2010Hearing Association National Outcome Measurement System Swallowing Scale, and the short version of the Korean Frenchay Aphasia Screening Test were used to assess physical impairment. The Functional Independence Measure and modified Rankin Scale were used to assess functional outcomes. All measurements were conducted up to 24\u2009months poststroke. A total of 297 patients were included, consisting of 235 with ischemic and 62 with hemorrhagic stroke. Except for the Functional Ambulatory Category and Functional Independence Measure, all physical impairments showed significant improvement up to 3\u2009months poststroke (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and reached a plateau. The Functional Ambulatory Category and Functional Independence Measure scores continued to improve up to 12 months poststroke (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) and reached a plateau. At 7\u2009days poststroke, 47.5% of patients had no disability (modified Rankin Scale score&lt;2), whereas at 24\u2009months poststroke, 76.4% of patients had no significant disability.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients showed rapid recovery from physical impairment up to 3\u2009months poststroke, with additional improvements in ambulatory function and independence observed up to 12\u2009months poststroke. Additionally, relatively favorable long\u2010term functional prognosis at 24\u2009months after onset was demonstrated. These results could provide insights into the proper management regarding functional outcomes of patients with isolated thalamic stroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032377","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T10:44:31Z","timestamp":1707821071000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010Term Functional Outcome in Patients With Isolated Thalamic Stroke: The KOSCO Study"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-6005","authenticated-orcid":false,"given":"Ho Seok","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of 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