{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:21:43Z","timestamp":1792686103818,"version":"4.5.0"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2023,12,5]]},"abstract":"<jats:sec sec-type=\"background\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Whether statin use\u00a0can reduce the risk of heart failure (HF) remains controversial. The present study evaluates the association between statin use and HF in patients with atrial fibrillation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients with newly diagnosed atrial fibrillation from 2010 to 2018 were included. An inverse probability of treatment weighting was used to balance baseline covariates between statin users (n=23\u2009239) and statin nonusers (n=29\u2009251). The primary outcome was incident HF. Cox proportional hazard models with competing risk regression were used to evaluate the risk of HF between statin users and nonusers. The median age of the cohort was 74.7\u2009years, and 47.3% were women. Over a median follow\u2010up of 5.1\u2009years, incident HF occurred in 3673 (15.8%) statin users and 5595 (19.1%) statin nonusers. Statin use was associated with a 19% lower risk of HF (adjusted subdistribution hazard ratio, 0.81 [95% CI, 0.78\u20130.85]). Restricted to the statin users, duration of statin use was measured during follow\u2010up; compared with short\u2010term use (3\u2009months to &lt;2\u2009years), there was a stepwise reduction in the risk of incident HF among those with 2 to &lt;4\u2009years of statin use (subdistribution hazard ratio, 0.86 [95% CI, 0.84\u20130.88]), 4 to &lt;6\u2009years of statin use (subdistribution hazard ratio, 0.74 [95% CI, 0.72\u20130.76]), and \u22656\u2009years of statin use (subdistribution hazard ratio, 0.71 [95% CI, 0.69\u20130.74]). Subgroup analysis showed consistent reductions in the risk of HF with statin use.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Statin use was associated with a decreased risk of incident HF in a duration\u2010dependent manner among patients with atrial fibrillation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.123.032378","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T11:26:24Z","timestamp":1701170784000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Statin Therapy Is Associated With a Lower Risk of Heart Failure in Patients With Atrial Fibrillation: A Population\u2010Based Study"],"prefix":"10.1161","volume":"12","author":[{"given":"Jia\u2010Yi","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of 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